MABN1182MI
MilliporeSigma™ Glutamine Synthetase, Mouse, Unlabeled, Clone: 11A3.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1182MI-Each-of-1 | In Stock | ₹ 41,307.51 |
MABN1182MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
Glutamine Synthetase
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P09606
Immunogen
GST-tagged recombinant rat glutamine synthetase internal fragment.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_058769
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
11A3.1
Conjugate
Unconjugated
Gene
Glul, Glns
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 11A3.1 targets an internal epitope within the C-terminal half of human and rat glutamine synthetase.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Glutamine synthetase (EC 4.1.1.15, EC 6.3.1.2; UniProt P09606; also known as Glutamate-ammonia ligase, Glutamate decarboxylase, GS) is encoded by the Glul (also known as Glns) gene (Gene ID 24957) in rat species
- Glutamine synthetase (GS) plays an essential role in nitrogen metabolism by catalyzing ATP-dependent condensation of glutamate and ammonia to form glutamine
- Three classes of GS exist, class I enzymes (GSI) are specific to prokaryotes and exist as oligomers of 12 identical subunits, class II enzymes (GSII) exist as decamer of identical subunits in eukaryotes and in some bacteria, while class III enzymes (GSIII) function as a double-ringed dodecamer of identical chains found in bacteroides fragilis and in butyrivibrio fibrisolvens
- GS is present predominantly in the brain, kidneys, and liver in mammals
- In the brain, GS is found primarily in astrocytes, where it participates in the the detoxification of ammonia via assimilation and termination of neurotransmitter signals via recyclization
- c-Myc promotes glutamine usage by upregulating glutaminase (GLS), which converts glutamine to glutamate in the TCA cycle, while in some cancer cells Myc-mediated thymine DNA glycosylase (TDG) transcription leads to GS upregulation due to TDG-dependent demethylation of the GS promoter
- GS upregulation promotes cancer cell survival under glutamine limitation, while GS silencing decreases cancer cell proliferation and xenograft tumor growth.
Compare Similar Items
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Antigen: Glutamine Synthetase
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P09606
Immunogen: GST-tagged recombinant rat glutamine synthetase internal fragment.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_058769
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 11A3.1
Conjugate: Unconjugated
Gene: Glul, Glns
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 11A3.1 targets an internal epitope within the C-terminal half of human and rat glutamine synthetase.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Glutamine Synthetase
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P09606
Immunogen:
GST-tagged recombinant rat glutamine synthetase internal fragment.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_058769
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
11A3.1
Conjugate:
Unconjugated
Gene:
Glul, Glns
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 11A3.1 targets an internal epitope within the C-terminal half of human and rat glutamine synthetase.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: GluR2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P19491
Immunogen: GST-tagged recombinant rat GluR2 N-terminal extracellular domain fragment.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001077280
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 14C12.2
Conjugate: Unconjugated
Gene: Gria2, Glur2
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 14C12.2 targets an epitope within the N-terminal extracellular domain present in all spliced isoforms of human, mouse, and rat GluR2 reported by UniProt (P42262, P23819, P19491).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
GluR2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P19491
Immunogen:
GST-tagged recombinant rat GluR2 N-terminal extracellular domain fragment.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001077280
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
14C12.2
Conjugate:
Unconjugated
Gene:
Gria2, Glur2
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 14C12.2 targets an epitope within the N-terminal extracellular domain present in all spliced isoforms of human, mouse, and rat GluR2 reported by UniProt (P42262, P23819, P19491).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: KLF6
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: NP_001153596
Immunogen: GST-tagged recombinant protein corresponding to human KLF6.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human, Mouse
Form: Purified
Applications: Immunohistochemistry, Western Blot
Clone: 12A8.3
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG2b κ
Antigen:
KLF6
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2bκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
NP_001153596
Immunogen:
GST-tagged recombinant protein corresponding to human KLF6.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunohistochemistry, Western Blot
Clone:
12A8.3
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG2b κ
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__