MABS1212MI

MilliporeSigma™ Geminin, Mouse, Unlabeled, Clone: 4B10.1,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABS1212MI-Each-of-1 In Stock ₹ 41,307.51

MABS1212MI - Each of 1

₹ 41,307.51

In Stock

Quantity

1

Base Price: ₹ 41,307.51

GST (18%): ₹ 7,435.352

Total Price: ₹ 48,742.862

Antigen

Geminin

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.

O75496

Immunogen

GST-tagged recombinant human geminin internal fragment.

Quantity

100 μL

Research Discipline

Signaling

Gene ID (Entrez)

NP_001238918

Target Species

Human

Form

Purified

Applications

Western Blot

Clone

4B10.1

Conjugate

Unconjugated

Gene

GMNN

Host Species

Mouse

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Clone 4B10.1 detects human geminin by targeting an internal epitope.

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Isotype

IgG2a κ

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Description

  • Geminin (UniProt O75496) is encoded by the GMNN gene (Gene ID 51053) in human
  • Geminin is a negative regulator of DNA-replication and the founding member of the Geminin family, whose members also include Idas (multicilin; McIdas) and GemC1 (Geminin coiled-coil domain-containing protein 1)
  • Geminin binds Cdt1 and inhibits the mini-chromosome maintenance complex (MCM) loading onto chromatin and pre-replication complex (preRC) formation
  • Geminin is a 209-amino acid protein that can form homodimer or heterodimers with either Idas or GemC1 via the middle coiled coil structure (a.a
  • 94-144 of Geminin) in a head-to-tail fashion
  • The same region in Geminin (a.a
  • 82-161) is also essential for Cdt1 interaction
  • A homeodomain-binding domain is located at the C-terminal region of Geminin (a.a
  • 170-190)
  • GemC1 is also implicated in DNA replication but at a later stage than Geminin
  • All three Geminin family members play important roles in cell proliferation and differentiation.

Compare Similar Items

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MilliporeSigma™

MABS1212MI

--


Antigen:
Geminin

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
O75496

Immunogen:
GST-tagged recombinant human geminin internal fragment.

Quantity:
100 μL

Research Discipline:
Signaling

Gene ID (Entrez):
NP_001238918

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
4B10.1

Conjugate:
Unconjugated

Gene:
GMNN

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone 4B10.1 detects human geminin by targeting an internal epitope.

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG2a κ

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MABS1215MI

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Antigen:
Calpain I/II, large subunit

Classification:
Monoclonal

Concentration:
__

Formulation:
Mouse monoclonal IgG2aκ ascites with 0.05% sodium azide.

Gene Accession No.:
P07384

Immunogen:
Purified m-calpain from rabbit skeletal muscle.

Quantity:
50 μL

Research Discipline:
Signaling

Gene ID (Entrez):
NP_001185797

Target Species:
Chicken, Human, Monkey, Rabbit, Rat

Form:
Ascites

Applications:
Immunocytochemistry, Western Blot

Clone:
1D10A7

Conjugate:
__

Gene:
__

Host Species:
Mouse

Purification Method:
Unpurified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.

Isotype:
IgG2a κ

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MABS1222MI

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Antigen:
MAN1B1

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
Q9UKM7

Immunogen:
GST-tagged recombinant protein corresponding to human MAN1B1.

Quantity:
200 μg

Research Discipline:
Signaling

Gene ID (Entrez):
NP_057303

Target Species:
Human, Rat

Form:
Purified

Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot

Clone:
1D6

Conjugate:
__

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG1 κ

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MABS1223

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Antigen:
SUMO-1

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Rat monoclonal hybridoma culture supernatant with 0.05% Sodium Azide.

Gene Accession No.:
P63165

Immunogen:
GST-tagged recombinant full-length human SUMO-1.

Quantity:
100 μL

Research Discipline:
Signaling

Gene ID (Entrez):
NP_001005781

Target Species:
Human

Form:
__

Applications:
Western Blot

Clone:
4D12

Conjugate:
Unconjugated

Gene:
SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43

Host Species:
Rat

Purification Method:
Unpurified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone 4D12 detects SUMO-1 and SUMO-1-modified (SUMOylated) proteins.

Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Isotype:
IgG2a κ