MABS1223

MilliporeSigma™ SUMO-1, Rat, Unlabeled, Clone: 4D12,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABS1223-Each-of-1 In Stock ₹ 34,965.81

MABS1223 - Each of 1

₹ 34,965.81

In Stock

Quantity

1

Base Price: ₹ 34,965.81

GST (18%): ₹ 6,293.846

Total Price: ₹ 41,259.656

Antigen

SUMO-1

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Rat monoclonal hybridoma culture supernatant with 0.05% Sodium Azide.

Gene Accession No.

P63165

Immunogen

GST-tagged recombinant full-length human SUMO-1.

Quantity

100 μL

Research Discipline

Signaling

Gene ID (Entrez)

NP_001005781

Target Species

Human

Isotype

IgG2a κ

Applications

Western Blot

Clone

4D12

Conjugate

Unconjugated

Gene

SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43

Host Species

Rat

Purification Method

Unpurified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Clone 4D12 detects SUMO-1 and SUMO-1-modified (SUMOylated) proteins.

Content And Storage

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

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Description

  • Small ubiquitin-related modifier 1 (UniProt P63165, P63166, Q5I0H3; also known as GAP-modifying protein 1, GMP1, Sentrin, SMT3 homolog 3, Ubiquitin-homology domain protein PIC1, Smt3C, SUMO-1, Ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1) is encoded by the human SUMO1 (also known as SMT3C, SMT3H3, UBL1,OK/SW-cl.43), mouse and rat Sumo1 (also known as Smt3c, Smt3h3, Ubl1) gene (Gene ID 7341, 22218, 301442, respectively)
  • SUMOylation, protein posttranslation modification by small ubiquitin-like modifier (SUMO), is a signaling event in many cellular processes
  • SUMO proteins are translated as immature precursors and subsequently converted to their mature forms through the activity of sentrin/SUMO-specific proteases (SENPs)
  • As is the case with ubiquitination, SUMOylation is a reversible process
  • SUMO E1 activating enzyme, E2 conjugating enzyme, and E3 ligase mediate SUMOylation of substrate proteins, while SENPs are responsible for the deSUMOylation
  • SUMOylation usually occurs at lysine residues in the consensus ΨKxD/E motif, although not all such lysines become SUMOylated and SUMOylation can also occur on lysine residues outside of this motif
  • SUMO2 and 3 share 97% identity at the amino acid level, while SUMO1 shares approximately 50% and SUMO4 shares about 87% identity with SUMO2/3
  • SUMO4 is the only SUMO member whose ctivation and conjugation has not been demonstrated
  • In addition to difference in their target substrates, SUMO2/3 can be SUMOylated and form chains, whereas SUMO1 cannot and may serve as chain terminator.

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MABS1223

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Antigen:
SUMO-1

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Rat monoclonal hybridoma culture supernatant with 0.05% Sodium Azide.

Gene Accession No.:
P63165

Immunogen:
GST-tagged recombinant full-length human SUMO-1.

Quantity:
100 μL

Research Discipline:
Signaling

Gene ID (Entrez):
NP_001005781

Target Species:
Human

Isotype:
IgG2a κ

Applications:
Western Blot

Clone:
4D12

Conjugate:
Unconjugated

Gene:
SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43

Host Species:
Rat

Purification Method:
Unpurified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone 4D12 detects SUMO-1 and SUMO-1-modified (SUMOylated) proteins.

Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

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MABS1225MI

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Antigen:
TXNIP

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
Q9H3M7

Immunogen:
Recombinant full-length human TXNIP protein.

Quantity:
100 μL

Research Discipline:
Signaling

Gene ID (Entrez):
NP_006463.3

Target Species:
Human

Isotype:
IgG1 κ

Applications:
Western Blot

Clone:
JY2

Conjugate:
Unconjugated

Gene:
TXNIP, VDUP1

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone JY2 detected TXNIP in adult mouse cardiomyocytes. No TXNIP target band was detected in cardiomyocytes from Txnip-null mice (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

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MABS1228MI

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Antigen:
ANKRD1/CARP

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
Q15327

Immunogen:
GST-tagged recombinant human ANKRD1/CARP fragment corresponding ankyrin repeats 4&5.

Quantity:
100 μg

Research Discipline:
Signaling

Gene ID (Entrez):
NP_055206

Target Species:
Human

Isotype:
IgG1 κ

Applications:
Western Blot

Clone:
12G8.2

Conjugate:
Unconjugated

Gene:
ANKRD1, C193, CARP, HA1A2

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

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Antigen:
SKP1

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
P63208

Immunogen:
GST-tagged recombinant human SKP1 internal fragment.

Quantity:
100 μg

Research Discipline:
Signaling

Gene ID (Entrez):
NP_008861

Target Species:
Human, Mouse

Isotype:
IgG2a κ

Applications:
Immunocytochemistry, Western Blot

Clone:
3F3.1

Conjugate:
__

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
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Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.