MABS1225MI
MilliporeSigma™ TXNIP, Mouse, Unlabeled, Clone: JY2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1225MI-Each-of-1 | In Stock | ₹ 37,453.03 |
MABS1225MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,453.03
GST (18%): ₹ 6,741.545
Total Price: ₹ 44,194.575
Antigen
TXNIP
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9H3M7
Immunogen
Recombinant full-length human TXNIP protein.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_006463.3
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
JY2
Conjugate
Unconjugated
Gene
TXNIP, VDUP1
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone JY2 detected TXNIP in adult mouse cardiomyocytes. No TXNIP target band was detected in cardiomyocytes from Txnip-null mice (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Thioredoxin-interacting protein (UniProt Q9H3M7; also known as Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1) is encoded by the TXNIP (also known as VDUP1) gene (Gene ID 10628) in human
- Thioredoxin interacting protein (TXNIP) is an alpha-arrestin protein that acts as an oxidative stress mediator that binds thioredoxin active cysteine residue and suppresses its antioxidant activity
- Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm
- TXNIP over-expression results in increased cellular ROS level and oxidative cell death, while TXNIP suppression enhances cellular resistance to oxidative injury
- TXNIP is also shown to inhibit cellular glucose uptake by downregulating plasma membrane localization of glucose transporter 1 (GLUT1)
- TXNIP is required for the maturation of natural killer cells
- Its expression is markedly down-regulated in tumor cells and its levels are correlated with clinical stage of cancer
- Mice with mutations or knockout of TXNIP gene are much more susceptible to carcinogenesis than wild-type mice, indicating its role in cancer suppression
- Ref.: Masutani, H., et al
- (2012)
- J
- Clin
- Biochem
- Nutr
- 50, 23-34.
Compare Similar Items
Show Difference
Antigen: TXNIP
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q9H3M7
Immunogen: Recombinant full-length human TXNIP protein.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_006463.3
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: JY2
Conjugate: Unconjugated
Gene: TXNIP, VDUP1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone JY2 detected TXNIP in adult mouse cardiomyocytes. No TXNIP target band was detected in cardiomyocytes from Txnip-null mice (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
TXNIP
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q9H3M7
Immunogen:
Recombinant full-length human TXNIP protein.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_006463.3
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
JY2
Conjugate:
Unconjugated
Gene:
TXNIP, VDUP1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone JY2 detected TXNIP in adult mouse cardiomyocytes. No TXNIP target band was detected in cardiomyocytes from Txnip-null mice (Yoshioka, J., et al. (2007). Circ. Res. 101(12):1328-1338).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: ANKRD1/CARP
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q15327
Immunogen: GST-tagged recombinant human ANKRD1/CARP fragment corresponding ankyrin repeats 4&5.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_055206
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 12G8.2
Conjugate: Unconjugated
Gene: ANKRD1, C193, CARP, HA1A2
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
ANKRD1/CARP
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q15327
Immunogen:
GST-tagged recombinant human ANKRD1/CARP fragment corresponding ankyrin repeats 4&5.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_055206
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
12G8.2
Conjugate:
Unconjugated
Gene:
ANKRD1, C193, CARP, HA1A2
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: SKP1
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P63208
Immunogen: GST-tagged recombinant human SKP1 internal fragment.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_008861
Target Species: Human, Mouse
Form: Purified
Applications: Immunocytochemistry, Western Blot
Clone: 3F3.1
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
SKP1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P63208
Immunogen:
GST-tagged recombinant human SKP1 internal fragment.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_008861
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunocytochemistry, Western Blot
Clone:
3F3.1
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Progesterone Receptor B
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P06401
Immunogen: Recombinant protein corresponding to the N-terminal of human Progesterone Receptor B.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000917
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Western Blot
Clone: 250/H11
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 250/H11 reacts with isoform 1 (isoform B; PR-B), but not isoform 2 (isoform A; PR-A). This clone is also expected to react with isoform 5 (delta4), but not isoform 3 or 4 (PR-M).
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Antigen:
Progesterone Receptor B
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P06401
Immunogen:
Recombinant protein corresponding to the N-terminal of human Progesterone Receptor B.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000917
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Western Blot
Clone:
250/H11
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 250/H11 reacts with isoform 1 (isoform B; PR-B), but not isoform 2 (isoform A; PR-A). This clone is also expected to react with isoform 5 (delta4), but not isoform 3 or 4 (PR-M).
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ