MilliporeSigma™ GluR2, Mouse, Unlabeled, Clone: 14C12.2,

Description

• Glutamate receptor 2 (UniProt P19491; also known as AMPA-selective glutamate receptor 2, GluA2, GluR-2, GluR-B, GluR-K2, GluR2, Glutamate receptor ionotropic, AMPA 2) is encoded by the Gria2 (also known as Glur2) gene (Gene ID 29627) in rat species
• Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells
• These receptors play important roles in neural communication, memory formation, learning, and regulation by mediating glutamate-dependent postsynaptic excitation
• Glutamate receptors are divided into two types, ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs)
• iGluRs form ion channel pores upon glutamate binding, while mGluRs indirectly activate ion channels on the plasma membrane via G protein-coupled signaling cascade
• Although all iGluRs and mGluRs bind glutamate, they do exhibit different binding activities toward chemical ligands, such as NMDA, kainate, AMPA, L-AP4, ACPD, L-QA, and such distinciton is used to divide these receptors further into subtypes
• Glutamate receptor 2 is an AMPA type iGluR, GluR-1 is initially produced with an N-terminal signal peptide sequence (a.a
• 1-24), the removal of which yields the mature receptor with 4 transmembrane helices (a.a
• 544-564, 592-610, 617-637, 813-833), having a large N-terminal extracellular domain (a.a
• 24-543), followed by two intracellular loops (a.a
• 565-591, 611-616), one extracellular loop (a.a
• 638-812) and a C-terminal cytoplasmic tail (a.a
• 834-883).