MABN1573MI
MilliporeSigma™ anti-Synapsin-2 Clone: 19.4,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1573MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABN1573MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
Synapsin-2
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q63537
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 19.4 reacts with both synapsin-2 spliced isoforms (IIa and IIb). Clone 19.4 does not react with any of the two synapsin-1 spliced isoforms (Vaccaro, P., et al. (1997). Brain Res. Mol. Brain Res. 52(1):1-16).
Content And Storage
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype
IgG2a κ
Applications
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
19.4
Formulation
Purified mouse monoclonal IgG2aκ antibody in PBS without preservatives.
Gene Symbols
Syn2
Immunogen
Purified recombinant rat synapsin-2.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001029192
Target Species
Human, Mouse, Rat
Form
Purified
Related Products
Description
- Specifically detects Synapsin-2 Clone: 19.4 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting Synapsin-2 (UniProt Q63537; also known as Synapsin II) is encoded by the Syn2 gene (Gene ID 29179) in rat species
- The synapins constitute a family of abundant neuronal phosphoproteins that regulate SV trafficking and neurotransmitter release at the pre-synaptic terminal
- Three genes exisit in mammals, encoding altogether 11 synapsin members by alternative splicings (Synapsin Ia & Ib by SYN1, Synapsin IIa & IIb by SYN2, Synapsin IIIa through IIIf by SYN3), Syn III is the most precociously expressed isoform that has a role in the early phases of neural development and is downregulated in mature neurons
- On the other hand, Syn I and Syn II are expressed at low levels at birth and their expressions progressively increase during synaptogenesis to reach a stable plateau at 1-2 months of life
- The NH2-terminal region is divided in A, B, and C domains and is highly conserved among synapsin isoforms
- Synapsins are regulated by postransloational phosphorylations
- Domain A contains PKA and CaMKI/IV phosphorylation sites, domain B contains MAPK/Erk phosphorylation sites, and domain C is phosphorylated by Src
- The c-terminal regions contain spliced domains and diverge among synapsin isoforms (domain D in Syn Ia and Ib, domain G in Syn Iia and Iib, domain H in Syn Iia, and domain J in Syn IIIa), although they all bear proline-rich regions binding to several SH3-containing proteins and additional phosphorylation sites for CaMKII, MAPK/Erk, and cdk1/5.
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Antigen: Synapsin-2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: Q63537
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 19.4 reacts with both synapsin-2 spliced isoforms (IIa and IIb). Clone 19.4 does not react with any of the two synapsin-1 spliced isoforms (Vaccaro, P., et al. (1997). Brain Res. Mol. Brain Res. 52(1):1-16).
Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype: IgG2a κ
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 19.4
Formulation: Purified mouse monoclonal IgG2aκ antibody in PBS without preservatives.
Gene Symbols: Syn2
Immunogen: Purified recombinant rat synapsin-2.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001029192
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
Synapsin-2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
Q63537
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 19.4 reacts with both synapsin-2 spliced isoforms (IIa and IIb). Clone 19.4 does not react with any of the two synapsin-1 spliced isoforms (Vaccaro, P., et al. (1997). Brain Res. Mol. Brain Res. 52(1):1-16).
Content And Storage:
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype:
IgG2a κ
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
19.4
Formulation:
Purified mouse monoclonal IgG2aκ antibody in PBS without preservatives.
Gene Symbols:
Syn2
Immunogen:
Purified recombinant rat synapsin-2.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001029192
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: beta-Arrestin-2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with spliced isoforms 1, 4, and 5 reported by UniProt (P32121). Reactivity toward spliced isoforms 2 & 3 has not been determined.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot, Immunohistochemistry (Paraffin)
Clone: 5E12.1
Formulation: __
Gene Symbols: ARRB2,ARB2,ARR2,BARR2
Immunogen: KLH-conjugated linear peptide corresponding to a sequence in the C-terminal region of human beta-Arrestin-2.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001244257
Target Species: Human, Rat
Form: Purified
Antigen:
beta-Arrestin-2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with spliced isoforms 1, 4, and 5 reported by UniProt (P32121). Reactivity toward spliced isoforms 2 & 3 has not been determined.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Clone:
5E12.1
Formulation:
__
Gene Symbols:
ARRB2,ARB2,ARR2,BARR2
Immunogen:
KLH-conjugated linear peptide corresponding to a sequence in the C-terminal region of human beta-Arrestin-2.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001244257
Target Species:
Human, Rat
Form:
Purified
Antigen: SCN2A
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: Q99250
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 5H10.2 targets an epitope in the C-terminal cytoplasmic domain.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Applications: Western Blot
Clone: 5H10.2
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: GST-tagged recombinant human SCN2A C-terminal cytoplasmic domain fragment.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001035232
Target Species: Human
Form: Purified
Antigen:
SCN2A
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
Q99250
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 5H10.2 targets an epitope in the C-terminal cytoplasmic domain.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Applications:
Western Blot
Clone:
5H10.2
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
GST-tagged recombinant human SCN2A C-terminal cytoplasmic domain fragment.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001035232
Target Species:
Human
Form:
Purified
Antigen: MATR3
Classification: Monoclonal
Conjugate: __
Gene Accession No.: P43243
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 3G1.1
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: MATR3; ALS21; KIAA0723; VCPDM
Immunogen: GST-tagged recombinant internal fragment from the N-terminal half of human martin-3.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001181884
Target Species: Human, Mouse
Form: Purified
Antigen:
MATR3
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
P43243
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
3G1.1
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
MATR3; ALS21; KIAA0723; VCPDM
Immunogen:
GST-tagged recombinant internal fragment from the N-terminal half of human martin-3.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001181884
Target Species:
Human, Mouse
Form:
Purified