MABS1237MI
MilliporeSigma™ NKCC1/2, Mouse, Unlabeled, Clone: T4,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1237MI-Each-of-1 | In Stock | ₹ 41,307.51 |
MABS1237MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
NKCC1/2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P55011
Immunogen
Recombinant human NKCC1 C-terminal fragment.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001037.1
Target Species
Avian
Form
Purified
Applications
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Clone
T4
Conjugate
Unconjugated
Gene
SLC12A1, SLC12A2, NKCC2, NKCC1
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone T4 recognizes both NKCC1 and NKCC2 by targeting a C-terminal region epitope exposed only under denaturing condition, and unaccessible for antibody binding when NKCC assumes its native conformation (Lytle, C., et al. (1995). Am. J. Physiol. 269(6 Pt 1):C1469-C1505).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Solute carrier family 12 member 1 (UniProt Q13621; a.k.a
- Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) and solute carrier family 12 member 2 (UniProt P55011; a.k.a
- Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) are encoded by the SLC12A1 (a.k.a
- NKCC2; Gene ID 6557) and SLC12A2 (a.k.a
- NKCC1; Gene ID 6558) gene, respectively, in human
- NKCC1 (SLC12A2) and NKCC2 (SLC12A1) belong to the subfamily of cation-chloride cotransporters (CCCs) that mediate electroneutral transport of sodium, potassium and chloride across the plasma membrane and are inhibited by bumetanide and furosemide-type of compounds
- NKCCs play an important role in cell volume regulation, where NKCC2 is involved in reabsorption of salt and osmotically-obliged water in renal epithelial cells, while NKCC1 has a major impact on intracellular chloride ion concentration ([Cl-]i) in vascular smooth muscle cells (VSMCs) and neuronal cells
- In primary hypertension, NKCC1 activity is increased in VSMCs and paraventricular nucleus (PVN) neurons, leading to elevated peripheral resistance in systemic circulation and activation of sympathetic nerve system (SNS), respectively
- Human NKCC1 and NKCC2 are 12-transmembrane proteins having their N- and C-terminal ends exposed at the cytoplasmic side (a.a
- 1-285 and 921-1212 of NKCC1; a.a
- 1-177 and 814-1099 of NKCC2).
Compare Similar Items
Show Difference
Antigen: NKCC1/2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P55011
Immunogen: Recombinant human NKCC1 C-terminal fragment.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001037.1
Target Species: Avian
Form: Purified
Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Clone: T4
Conjugate: Unconjugated
Gene: SLC12A1, SLC12A2, NKCC2, NKCC1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone T4 recognizes both NKCC1 and NKCC2 by targeting a C-terminal region epitope exposed only under denaturing condition, and unaccessible for antibody binding when NKCC assumes its native conformation (Lytle, C., et al. (1995). Am. J. Physiol. 269(6 Pt 1):C1469-C1505).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
NKCC1/2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P55011
Immunogen:
Recombinant human NKCC1 C-terminal fragment.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001037.1
Target Species:
Avian
Form:
Purified
Applications:
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Clone:
T4
Conjugate:
Unconjugated
Gene:
SLC12A1, SLC12A2, NKCC2, NKCC1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone T4 recognizes both NKCC1 and NKCC2 by targeting a C-terminal region epitope exposed only under denaturing condition, and unaccessible for antibody binding when NKCC assumes its native conformation (Lytle, C., et al. (1995). Am. J. Physiol. 269(6 Pt 1):C1469-C1505).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: CYP2J2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: A full-length recombinant human cytochrome P450 2J2.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000766
Target Species: Mouse, Human
Form: Purified
Applications: Western Blot, Inhibition Assays
Clone: 6-5-20-8
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 6-5-20-8 detects cytochrome p450 2J2 in human and murine species.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Antigen:
CYP2J2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
A full-length recombinant human cytochrome P450 2J2.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000766
Target Species:
Mouse, Human
Form:
Purified
Applications:
Western Blot, Inhibition Assays
Clone:
6-5-20-8
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 6-5-20-8 detects cytochrome p450 2J2 in human and murine species.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Antigen: BIG2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: GST-tagged recombinant fragment corresponding to 249 amino acids from the N-terminal region of human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_006411
Target Species: Human
Form: Purified
Applications: Western Blot, Immunoprecipitation, Immunocytochemistry
Clone: 56
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 56 specifically detects BIG2 in human. It targets an epitope within amino acids 9-257 in the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
BIG2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant fragment corresponding to 249 amino acids from the N-terminal region of human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_006411
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Immunoprecipitation, Immunocytochemistry
Clone:
56
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 56 specifically detects BIG2 in human. It targets an epitope within amino acids 9-257 in the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: BIG1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: GST-tagged recombinat fragment corresponding to 311 amino acids from human Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1).
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_006412
Target Species: Human
Form: Purified
Applications: Western Blot, Immunocytochemistry
Clone: 102
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 102 specifically detects BIG1 protein in human and targets an epitope within amino acids 212-522 in the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
BIG1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
GST-tagged recombinat fragment corresponding to 311 amino acids from human Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1).
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_006412
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Immunocytochemistry
Clone:
102
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 102 specifically detects BIG1 protein in human and targets an epitope within amino acids 212-522 in the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ