MABS1476MI
MilliporeSigma™ SGK1, Mouse, Unlabeled, Clone: 1G2.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1476MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABS1476MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
SGK1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O00141
Immunogen
GST-tagged recombinant human SGK1 fragment corresponding to the region N-terminal to the kinase domain.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_005618
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1G2.1
Conjugate
Unconjugated
Gene
SGK1, SGK
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1G2.1 was raised against SGK1 N-terminal fragment, reactivity towards human spliced isoforms 2-5 and murine spliced isoforms 2 and 3 are possible only if the epitope lies outside the first 25-amino acids of isoform 1.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1; UniProt O00141; also known as Serum/glucocorticoid-regulated kinase 1) is encoded by the SGK1 (also known as SGK) gene (Gene ID 6446) in human
- SGK1 is a serine/threonine kinase that is induced in response to a variety of stimuli, including serum, osmotic shock, FSH, glucocorticoids, and mineralocorticoids
- It is expressed in most tissues with highest levels observed in in the pancreas, followed by placenta, kidney, and lung
- SGK1 is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis
- It is also reported to play an important role in cellular stress response
- It is also involved in the regulation of renal sodium retention and potassium elimination
- SGK1 activity is regulated by phosphorylation and is activated by phosphorylation on Ser422 by mTORC2
- This phosphorylation transforms it into a substrate for PDPK1, which phosphorylates it on Thr256
- Phosphorylation on Ser397 and Ser401 are also considered to be essential for its activity
- It is negatively regulated by ubiquitination and proteasome degradation
- High levels of expression of SGK1 gene may contribute to conditions such as hypertension and diabetic nephropathy
- SGK1 has been reported to be up-regulated in non-small cell lung cancer (NSCLC) and its over-expression promotes the growth and migration of NSCLC cells via GSK-3 beta phosphorylation and activation of beta-catenin/TCF signaling
- Ref.: Xiaobo, Y et al
- (2016) Gene 576, 339-346.
Compare Similar Items
Show Difference
Antigen: SGK1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: O00141
Immunogen: GST-tagged recombinant human SGK1 fragment corresponding to the region N-terminal to the kinase domain.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_005618
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 1G2.1
Conjugate: Unconjugated
Gene: SGK1, SGK
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1G2.1 was raised against SGK1 N-terminal fragment, reactivity towards human spliced isoforms 2-5 and murine spliced isoforms 2 and 3 are possible only if the epitope lies outside the first 25-amino acids of isoform 1.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
SGK1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
O00141
Immunogen:
GST-tagged recombinant human SGK1 fragment corresponding to the region N-terminal to the kinase domain.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_005618
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
1G2.1
Conjugate:
Unconjugated
Gene:
SGK1, SGK
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1G2.1 was raised against SGK1 N-terminal fragment, reactivity towards human spliced isoforms 2-5 and murine spliced isoforms 2 and 3 are possible only if the epitope lies outside the first 25-amino acids of isoform 1.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: mTOR
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: NP_063971
Immunogen: GST-tagged recombinant protein corresponding to rat mTOR.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human, Rat
Form: Purified
Applications: Immunoprecipitation, Western Blot
Clone: F11
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG1 κ
Antigen:
mTOR
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
NP_063971
Immunogen:
GST-tagged recombinant protein corresponding to rat mTOR.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human, Rat
Form:
Purified
Applications:
Immunoprecipitation, Western Blot
Clone:
F11
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG1 κ
Antigen: HGK
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: O95819
Immunogen: Recombinant protein corresponding to human HGK.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001229488
Target Species: Rat
Form: Purified
Applications: Western Blot
Clone: 2H1.1
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
HGK
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
O95819
Immunogen:
Recombinant protein corresponding to human HGK.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001229488
Target Species:
Rat
Form:
Purified
Applications:
Western Blot
Clone:
2H1.1
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: phospho-GRK2 (Ser670)
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: NP_001610
Immunogen: KLH-conjugated linear peptide corresponding to human GRK2 phosphorylated at Ser670.
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Immunoprecipitation, Inhibition Assays, Western Blot
Clone: 15G11.1
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG2b κ
Antigen:
phospho-GRK2 (Ser670)
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2bκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
NP_001610
Immunogen:
KLH-conjugated linear peptide corresponding to human GRK2 phosphorylated at Ser670.
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Immunoprecipitation, Inhibition Assays, Western Blot
Clone:
15G11.1
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG2b κ