MABS1208MI
MilliporeSigma™ LDL Receptor, Mouse, Unlabeled, Clone: 2H7.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1208MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABS1208MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
LDL Receptor
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P01130
Immunogen
GST-tagged recombinant human LDL receptor extracellular fragment corresponding to class A domains 1-3.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_000518
Target Species
Human
Form
Purified
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
2H7.1
Conjugate
Unconjugated
Gene
LDLR, FH, FHC
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with spliced isoforms 1 and 5 reported by UniProt P01130). Reactivity toward spliced isoforms 2, 3, 4, and 6 has not been determined.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Low-density lipoprotein receptor (UniProt P01130; also known as LDL receptor) is encoded by the LDLR (also known as FH, FHC) gene (Gene ID 3949) in human
- Low-density lipoprotein (LDL) receptor recognizes the apoprotein B100 embedded in the outer phospholipid layer of cholesterol-rich LDL particles and mediates their remval by endocytosis via clathrin-coated pits
- LDL receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL)
- LDLR gene mutations are known causes of familial hypercholesterolaemia (FH)
- LDL receptor is initially produced with a signal peptide sequence (a.a
- 1-21), the removal of which yields the mature single transmembrane (a.a
- 789-810) protein wiht a C-terminal cytoplasmic tail (a.a
- 811-860) and a large N-terminal extracellular region (a.a
- 22-788) that contains seven class A (a.a
- 25-313) and six class B (a.a
- 397-658) LDLR repeats, as well as three EGF-like domains (a.a
- 314-353, 354-393, 663-712)
- LDL-A repeats mediate LDL binding, repeats 2-7 are required for ApoB binding, while only repeat 5 is required for ApoE binding
- The class B (LDL-B) repeats region adopts a beta-propeller conformation and is believed to be responsible for the pH-dependent release of LDL in the endosome
- The cytoplasmic tail contains a signal sequence important for localizing the receptors to clathrin-coated pits and for triggering receptor-mediated endocytosis upon LDL binding.
Compare Similar Items
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Antigen: LDL Receptor
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P01130
Immunogen: GST-tagged recombinant human LDL receptor extracellular fragment corresponding to class A domains 1-3.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000518
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 2H7.1
Conjugate: Unconjugated
Gene: LDLR, FH, FHC
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with spliced isoforms 1 and 5 reported by UniProt P01130). Reactivity toward spliced isoforms 2, 3, 4, and 6 has not been determined.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
LDL Receptor
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P01130
Immunogen:
GST-tagged recombinant human LDL receptor extracellular fragment corresponding to class A domains 1-3.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000518
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
2H7.1
Conjugate:
Unconjugated
Gene:
LDLR, FH, FHC
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with spliced isoforms 1 and 5 reported by UniProt P01130). Reactivity toward spliced isoforms 2, 3, 4, and 6 has not been determined.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: Geminin
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: O75496
Immunogen: GST-tagged recombinant human geminin internal fragment.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_001238918
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 4B10.1
Conjugate: Unconjugated
Gene: GMNN
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 4B10.1 detects human geminin by targeting an internal epitope.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Geminin
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
O75496
Immunogen:
GST-tagged recombinant human geminin internal fragment.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001238918
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
4B10.1
Conjugate:
Unconjugated
Gene:
GMNN
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 4B10.1 detects human geminin by targeting an internal epitope.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Calpain I/II, large subunit
Classification: Monoclonal
Concentration: __
Formulation: Mouse monoclonal IgG2aκ ascites with 0.05% sodium azide.
Gene Accession No.: P07384
Immunogen: Purified m-calpain from rabbit skeletal muscle.
Quantity: 50 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_001185797
Target Species: Chicken, Human, Monkey, Rabbit, Rat
Form: Ascites
Applications: Immunocytochemistry, Western Blot
Clone: 1D10A7
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype: IgG2a κ
Antigen:
Calpain I/II, large subunit
Classification:
Monoclonal
Concentration:
__
Formulation:
Mouse monoclonal IgG2aκ ascites with 0.05% sodium azide.
Gene Accession No.:
P07384
Immunogen:
Purified m-calpain from rabbit skeletal muscle.
Quantity:
50 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001185797
Target Species:
Chicken, Human, Monkey, Rabbit, Rat
Form:
Ascites
Applications:
Immunocytochemistry, Western Blot
Clone:
1D10A7
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype:
IgG2a κ
Antigen: MAN1B1
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q9UKM7
Immunogen: GST-tagged recombinant protein corresponding to human MAN1B1.
Quantity: 200 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_057303
Target Species: Human, Rat
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 1D6
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
MAN1B1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q9UKM7
Immunogen:
GST-tagged recombinant protein corresponding to human MAN1B1.
Quantity:
200 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_057303
Target Species:
Human, Rat
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
1D6
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ