MABS190625
MULT1, Rat anti-Mouse, Clone: 1D6, Millipore Sigma™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS190625-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS190625 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
MULT1
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
Ulbp1
Immunogen
Recombinant fragment corresponding to 186 amino acids from the extracellular domain of murine UL16-binding protein-like transcript 1 splicing variant (MULT-1).
Quantity
25 μg
Research Discipline
Signaling
Gene ID (Entrez)
NA
Target Species
Mouse
Form
Purified
Applications
ELISA, Flow Cytometry, Immunocytochemistry
Clone
1D6
Dilution
Immunocytochemistry Analysis: A representative lot detected MULT1 in Immunocytochemistry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).Flow Cytometry Analysis: A representative lot detected MULT1 in Flow Cytometry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).ELISA Analysis: A representative lot detected MULT1 in ELISA applications (Sheppard, S., et. al. (2017). Nat Commun. 8:13930; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).
Gene Alias
MULT-1;ULBP1;mouse UL16-binding protein-like Transcript 1;NKG2DL;NKG2D ligand
Host Species
Rat
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1D6 is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant in mouse.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Anti-MULT1, clone 1D6, Cat
- No
- MABS1906, is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant and has been tested for use in ELISA, Flow Cytometry, and Immunocytochemistry
- UL16-binding protein-like transcript 1 splicing variant (UniProt: Q330P3; also known as MULT1, MULT-1, ULBP1) is encoded by the Ulbp1 gene in murine species
- MULT-1 is a MHC Class I-like molecule that serves as a high affinity ligand for natural Killer Group 2D (NKG2D) receptor
- It is a type I transmembrane protein that is synthesized with a signal peptide (aa 1-25), which is subsequently cleaved off to generate the mature form
- Its transmembrane domain is localized to amino acids 124 to 146 and its extracellular domain contains an alpha 1 and alpha 2 like domain with two intrachain disulfide bonds
- MULT-1 expression is reported to be low or absent in normal adult tissues, however, under conditions of stress and in tumor cells its levels are elevated
- Many tumor cells are shown to release soluble NKG2D ligands through proteolytic shedding, alternative splicing, or exosome secretion
- In mice MULT-1 is shown to cause NK cell activation and tumor rejection
- Mice subjected to cytomegalovirus (MCMV) infection display strong expression of Ulbp1 (Mult1) gene, but surface expression of MULT-1 is nevertheless completely abolished by the virus
- Fc receptor fcr-1 is reported to down-regulate MULT-1 levels by interfering with surface MULT-1 and causing its subsequent degradation in lysosomes
- This effect of Fcr-1 can be completely abolished by imipramine (Cat
- No
- I0899), which blocks AP2-mediated clathrin pathway
- (Ref.: Lenac, T., et al
- (2006)
- J
- Exp
- Med
- 203(8); 1843 1850; Krmpotic, A., et al
- (2005)
- J
- Exp
- Med
- 201(2): 211-220; Deng, W., et al
- (2015)
- Science
- 348(6230); 136-139).
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Antigen: MULT1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Ulbp1
Immunogen: Recombinant fragment corresponding to 186 amino acids from the extracellular domain of murine UL16-binding protein-like transcript 1 splicing variant (MULT-1).
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): NA
Target Species: Mouse
Form: Purified
Applications: ELISA, Flow Cytometry, Immunocytochemistry
Clone: 1D6
Dilution: Immunocytochemistry Analysis: A representative lot detected MULT1 in Immunocytochemistry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).Flow Cytometry Analysis: A representative lot detected MULT1 in Flow Cytometry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).ELISA Analysis: A representative lot detected MULT1 in ELISA applications (Sheppard, S., et. al. (2017). Nat Commun. 8:13930; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).
Gene Alias: MULT-1;ULBP1;mouse UL16-binding protein-like Transcript 1;NKG2DL;NKG2D ligand
Host Species: Rat
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1D6 is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant in mouse.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
MULT1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Ulbp1
Immunogen:
Recombinant fragment corresponding to 186 amino acids from the extracellular domain of murine UL16-binding protein-like transcript 1 splicing variant (MULT-1).
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NA
Target Species:
Mouse
Form:
Purified
Applications:
ELISA, Flow Cytometry, Immunocytochemistry
Clone:
1D6
Dilution:
Immunocytochemistry Analysis: A representative lot detected MULT1 in Immunocytochemistry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).Flow Cytometry Analysis: A representative lot detected MULT1 in Flow Cytometry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).ELISA Analysis: A representative lot detected MULT1 in ELISA applications (Sheppard, S., et. al. (2017). Nat Commun. 8:13930; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).
Gene Alias:
MULT-1;ULBP1;mouse UL16-binding protein-like Transcript 1;NKG2DL;NKG2D ligand
Host Species:
Rat
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1D6 is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant in mouse.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Ketohexokinase Isoform C
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: KHK
Immunogen: A full-length human recombinant Ketohexokinase, isoform C.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000212
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 5F1-3F5
Dilution: Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Gene Alias: EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Ketohexokinase Isoform C
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
KHK
Immunogen:
A full-length human recombinant Ketohexokinase, isoform C.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000212
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
5F1-3F5
Dilution:
Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Gene Alias:
EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Ketohexokinase Isoform C
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: KHK
Immunogen: A full-length human recombinant Ketohexokinase, isoform C.
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000212
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 5F1-3F5
Dilution: Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Gene Alias: EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Ketohexokinase Isoform C
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
KHK
Immunogen:
A full-length human recombinant Ketohexokinase, isoform C.
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000212
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
5F1-3F5
Dilution:
Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Gene Alias:
EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Signal peptide peptidase-like 3
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SPPL3;IMP2
Immunogen: KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Signal peptide peptidase-like 3.
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Immunoprecipitation, Western Blot
Clone: 7F9
Dilution: Western Blotting Analysis: A representative lot detected Signal peptide peptidase-like 3 in Western Blotting applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9; Voss, M., et. al. (2014). EMBO J. 33(24):2890-905; Fleck, D., et. al. (2016). J Biol Chem. 291(1):318-33).Immunoprecipitation Analysis: A representative lot detected Signal peptide peptidase-like 3 in Immunoprecipitation applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9).
Gene Alias: Signal peptide peptidase-like 3;SPP-like 3;Intramembrane protease 2;IMP-2;Presenilin homologous protein 1;PSH1;Presenilin-like protein 4
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 7F9 detects Signal peptide peptidase-like 3 in human cells. it targets an epitope within 15 amino acids from the C-terminal half. Immunogen sequence is conserved in all three isoforms.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Antigen:
Signal peptide peptidase-like 3
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SPPL3;IMP2
Immunogen:
KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Signal peptide peptidase-like 3.
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Immunoprecipitation, Western Blot
Clone:
7F9
Dilution:
Western Blotting Analysis: A representative lot detected Signal peptide peptidase-like 3 in Western Blotting applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9; Voss, M., et. al. (2014). EMBO J. 33(24):2890-905; Fleck, D., et. al. (2016). J Biol Chem. 291(1):318-33).Immunoprecipitation Analysis: A representative lot detected Signal peptide peptidase-like 3 in Immunoprecipitation applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9).
Gene Alias:
Signal peptide peptidase-like 3;SPP-like 3;Intramembrane protease 2;IMP-2;Presenilin homologous protein 1;PSH1;Presenilin-like protein 4
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 7F9 detects Signal peptide peptidase-like 3 in human cells. it targets an epitope within 15 amino acids from the C-terminal half. Immunogen sequence is conserved in all three isoforms.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1