PIMA532023
Caspase 8 Recombinant Rabbit Monoclonal Antibody (SZ01-08), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532023-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA532023 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
Caspase 8
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q14790
Gene Symbols
Casp8
Immunogen
Synthetic peptide within Human Caspase-8 aa 207-256
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SZ01-08
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
841
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
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Antigen: Caspase 8
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: Q14790
Gene Symbols: Casp8
Immunogen: Synthetic peptide within Human Caspase-8 aa 207-256
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SZ01-08
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 841
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Caspase 8
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
Q14790
Gene Symbols:
Casp8
Immunogen:
Synthetic peptide within Human Caspase-8 aa 207-256
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SZ01-08
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
841
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Phospho-ERK1/ERK2 (Thr202,Thr185)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P27361, P28482
Gene Symbols: MAPK1, MAPK3
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr185 of human Erk2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SZ2-4
Conjugate: Unconjugated
Gene: MAPK1
Gene Alias: 12559, 9030612K14Rik, AA407128, AU018647, BcDNA:RE08694, C78273, CG12559, CG12559-PA, CG12559-PC, CG12559-PD, CG12559-PE, CG12559-PG, CG12559-PH, CG12559-PI, CG18732, CT34260, CT39192, DERK, D-ERK, DERK-A, Diphospho-ERK, dm-dpERK, Dmel\CG12559, Dmel_CG12559, DmErk, DmERKA, DmERK-A, DmMAPK, dpERK, dp-ERK, dpERK1, dpMAPK, drosophila ERK, Dsor2, E(sina)7, EC2-1, EK2-1, enhancer of seven in absentia 7, ERK, Erk MAP kinase, Erk/Map kinase, ERK/rolled, Erk1, Erk-1, erk1 erk2, Erk1/2, ERK1b, ERK2, ERK-2, ERKA, ERK-A, ERT1, ERT2, Esrk1, extracellular signal-regulated kinase, extracellular signal-regulated kinase (ERK2), extracellular signal-regulated kinase 1, Extracellular signal-regulated kinase 2, extracellular signal-regulated kinase A, extracellular signal-regulated kinase-1, extracellular signal-regulated kinase-2, extracellular signal-related kinase 1, Extracellular-regulated kinase A, extracellular-signal-regulated kinase 2, Extracellular-signal-related kinase A, EY2-2, fi06b09, GroupI
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 5594, 5595
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Phospho-ERK1/ERK2 (Thr202,Thr185)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P27361, P28482
Gene Symbols:
MAPK1, MAPK3
Immunogen:
Synthetic phospho-peptide corresponding to residues surrounding Thr185 of human Erk2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SZ2-4
Conjugate:
Unconjugated
Gene:
MAPK1
Gene Alias:
12559, 9030612K14Rik, AA407128, AU018647, BcDNA:RE08694, C78273, CG12559, CG12559-PA, CG12559-PC, CG12559-PD, CG12559-PE, CG12559-PG, CG12559-PH, CG12559-PI, CG18732, CT34260, CT39192, DERK, D-ERK, DERK-A, Diphospho-ERK, dm-dpERK, Dmel\CG12559, Dmel_CG12559, DmErk, DmERKA, DmERK-A, DmMAPK, dpERK, dp-ERK, dpERK1, dpMAPK, drosophila ERK, Dsor2, E(sina)7, EC2-1, EK2-1, enhancer of seven in absentia 7, ERK, Erk MAP kinase, Erk/Map kinase, ERK/rolled, Erk1, Erk-1, erk1 erk2, Erk1/2, ERK1b, ERK2, ERK-2, ERKA, ERK-A, ERT1, ERT2, Esrk1, extracellular signal-regulated kinase, extracellular signal-regulated kinase (ERK2), extracellular signal-regulated kinase 1, Extracellular signal-regulated kinase 2, extracellular signal-regulated kinase A, extracellular signal-regulated kinase-1, extracellular signal-regulated kinase-2, extracellular signal-related kinase 1, Extracellular-regulated kinase A, extracellular-signal-regulated kinase 2, Extracellular-signal-related kinase A, EY2-2, fi06b09, GroupI
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
5594, 5595
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: ERK2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P28482, P63085, P63086
Gene Symbols: MAPK1
Immunogen: Synthetic peptide within Human ERK2 aa 311-360
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SZ25-01
Conjugate: Unconjugated
Gene: MAPK1
Gene Alias: 9030612K14Rik, AA407128, AU018647, C78273, ERK, ERK2, ERK-2, ERT1, extracellular signal-regulated kinase 2, extracellular signal-regulated kinase-2, extracellular-signal-regulated kinase 2, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, Mapk, MAPK 1, MAPK 2, Mapk1, MAPK2, mitogen activated protein kinase 1, mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, p38, p40, p41, p41mapk, P42MAPK, p42-MAPK, Prkm1, PRKM2, protein tyrosine kinase ERK2
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 116590, 26413, 5594
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
ERK2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P28482, P63085, P63086
Gene Symbols:
MAPK1
Immunogen:
Synthetic peptide within Human ERK2 aa 311-360
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SZ25-01
Conjugate:
Unconjugated
Gene:
MAPK1
Gene Alias:
9030612K14Rik, AA407128, AU018647, C78273, ERK, ERK2, ERK-2, ERT1, extracellular signal-regulated kinase 2, extracellular signal-regulated kinase-2, extracellular-signal-regulated kinase 2, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, Mapk, MAPK 1, MAPK 2, Mapk1, MAPK2, mitogen activated protein kinase 1, mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, p38, p40, p41, p41mapk, P42MAPK, p42-MAPK, Prkm1, PRKM2, protein tyrosine kinase ERK2
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
116590, 26413, 5594
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: pro-Caspase 3
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P42574, P70677
Gene Symbols: CASP3
Immunogen: Synthetic peptide within Human pro Caspase-3 aa 18-67
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SZ02-08
Conjugate: Unconjugated
Gene: CASP3
Gene Alias: A830040C14Rik, AC-3, Apopain, Casp3, CASP-3, caspase 3, caspase 3, apoptosis related cysteine protease, caspase 3, apoptosis-related cysteine peptidase, caspase 3, apoptosis-related cysteine protease, caspase-3, Caspase-3 subunit p12, Caspase-3 subunit p17, CC3, Cpp32, CPP-32, CPP32B, cysteine protease CPP32, LICE, mLdy, PARP cleavage protease, procaspase3, protein Yama, SCA-1, SREBP cleavage activity 1, Yama
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 12367, 836
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
pro-Caspase 3
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P42574, P70677
Gene Symbols:
CASP3
Immunogen:
Synthetic peptide within Human pro Caspase-3 aa 18-67
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SZ02-08
Conjugate:
Unconjugated
Gene:
CASP3
Gene Alias:
A830040C14Rik, AC-3, Apopain, Casp3, CASP-3, caspase 3, caspase 3, apoptosis related cysteine protease, caspase 3, apoptosis-related cysteine peptidase, caspase 3, apoptosis-related cysteine protease, caspase-3, Caspase-3 subunit p12, Caspase-3 subunit p17, CC3, Cpp32, CPP-32, CPP32B, cysteine protease CPP32, LICE, mLdy, PARP cleavage protease, procaspase3, protein Yama, SCA-1, SREBP cleavage activity 1, Yama
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
12367, 836
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid