PIMA532189
CD11a (LFA-1alpha) Recombinant Rabbit Monoclonal Antibody (SC56-01), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532189-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA532189 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
CD11a (LFA-1alpha)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P20701
Gene Symbols
ITGAL
Immunogen
Synthetic peptide within Human CD11a aa 1135-1170
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SC56-01
Conjugate
Unconjugated
Gene
ITGAL
Gene Alias
(p180), alpha L integrin, antigen CD11A (p180), antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, antigen CD11A p180, CD11 antigen-like family member A, CD11a, integrin alpha L, integrin alphaL, integrin alpha-L, integrin alpha-L precursor, integrin gene promoter, integrin subunit alpha L, integrin surface receptor, integrin, alpha L, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide), ITGAL, Leukocyte adhesion glycoprotein LFA-1 alpha chain, leukocyte function-associated molecule 1 alpha chain, LFA-1, LFA-1 alpha, LFA1A, LFA-1A, Ly-15, Ly-21, lymphocyte antigen 15, lymphocyte function associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen 1, lymphocyte function-associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen-1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3683
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin
- CD11a is implicated in activation of LFA-1 complex
- CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling
- CD11a is expressed on the plasma membrane of leukocytes in a low-affinity conformation
- Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of CD11a to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3
- CD11a is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions
- Blocking of CD11a function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases
- For example, humanized anti- CD11a antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity
- Two transcript variants encoding different isoforms of CD11a have been found
- Diseases associated with CD11a dysfunction include benign cephalic histiocytosis and leukocyte adhesion deficiency.
Compare Similar Items
Show Difference
Antigen: CD11a (LFA-1alpha)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P20701
Gene Symbols: ITGAL
Immunogen: Synthetic peptide within Human CD11a aa 1135-1170
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SC56-01
Conjugate: Unconjugated
Gene: ITGAL
Gene Alias: (p180), alpha L integrin, antigen CD11A (p180), antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, antigen CD11A p180, CD11 antigen-like family member A, CD11a, integrin alpha L, integrin alphaL, integrin alpha-L, integrin alpha-L precursor, integrin gene promoter, integrin subunit alpha L, integrin surface receptor, integrin, alpha L, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide), ITGAL, Leukocyte adhesion glycoprotein LFA-1 alpha chain, leukocyte function-associated molecule 1 alpha chain, LFA-1, LFA-1 alpha, LFA1A, LFA-1A, Ly-15, Ly-21, lymphocyte antigen 15, lymphocyte function associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen 1, lymphocyte function-associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen-1
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 3683
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
CD11a (LFA-1alpha)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P20701
Gene Symbols:
ITGAL
Immunogen:
Synthetic peptide within Human CD11a aa 1135-1170
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SC56-01
Conjugate:
Unconjugated
Gene:
ITGAL
Gene Alias:
(p180), alpha L integrin, antigen CD11A (p180), antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, antigen CD11A p180, CD11 antigen-like family member A, CD11a, integrin alpha L, integrin alphaL, integrin alpha-L, integrin alpha-L precursor, integrin gene promoter, integrin subunit alpha L, integrin surface receptor, integrin, alpha L, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide), ITGAL, Leukocyte adhesion glycoprotein LFA-1 alpha chain, leukocyte function-associated molecule 1 alpha chain, LFA-1, LFA-1 alpha, LFA1A, LFA-1A, Ly-15, Ly-21, lymphocyte antigen 15, lymphocyte function associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen 1, lymphocyte function-associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen-1
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
3683
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: TSC2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P49815, P49816, Q61037
Gene Symbols: TSC2
Immunogen: Synthetic peptide within Human Tuberin aa 1760-1807
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Clone: SC05-59
Conjugate: Unconjugated
Gene: TSC2
Gene Alias: LAM, Nafld, OTTHUMP00000198394, PPP1R160, protein phosphatase 1, regulatory subunit 160, Rc, renal carcinoma, Tcs2, Tsc2, TSC4, Tuberin, tuberous sclerosis 2, tuberous sclerosis 2 homolog protein, tuberous sclerosis 2 protein, Tuberous sclerosis 2 protein homolog
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 22084, 24855, 7249
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
TSC2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P49815, P49816, Q61037
Gene Symbols:
TSC2
Immunogen:
Synthetic peptide within Human Tuberin aa 1760-1807
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunohistochemistry, Western Blot
Clone:
SC05-59
Conjugate:
Unconjugated
Gene:
TSC2
Gene Alias:
LAM, Nafld, OTTHUMP00000198394, PPP1R160, protein phosphatase 1, regulatory subunit 160, Rc, renal carcinoma, Tcs2, Tsc2, TSC4, Tuberin, tuberous sclerosis 2, tuberous sclerosis 2 homolog protein, tuberous sclerosis 2 protein, Tuberous sclerosis 2 protein homolog
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
22084, 24855, 7249
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: JNK2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P45984, P49186, Q9WTU6
Gene Symbols: MAPK9
Immunogen: Synthetic peptide within Human JNK2 aa 341-394
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SC05-85
Conjugate: Unconjugated
Gene: MAPK9
Gene Alias: AI851083, c-Jun kinase 2, c-Jun N-terminal kinase 2, I79_012561, JNK, JNK/SAPK alpha, JNK1, JNK1A2, JNK2, JNK21B1/2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK-46, JNK-55, Jun kinase, MAP kinase 10, MAP kinase 8, MAP kinase 9, MAPK 10, MAPK 9, MAPK10, MAPK8, Mapk9, mitogen activated protein kinase 9, mitogen-activated protein kinase 9, OTTHUMP00000161542, OTTHUMP00000161543, p54a, p54-alpha, p54aSAPK, PRKM8, PRKM9, protein kinase, mitogen-activated 9, SAPK, SAPK1, SAPK1a, SAPK1c, SAPK-alpha, stress activated protein kinase alpha II, stress-activated protein kinase 1a, Stress-activated protein kinase JNK2
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 26420, 50658, 5601
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
JNK2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P45984, P49186, Q9WTU6
Gene Symbols:
MAPK9
Immunogen:
Synthetic peptide within Human JNK2 aa 341-394
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SC05-85
Conjugate:
Unconjugated
Gene:
MAPK9
Gene Alias:
AI851083, c-Jun kinase 2, c-Jun N-terminal kinase 2, I79_012561, JNK, JNK/SAPK alpha, JNK1, JNK1A2, JNK2, JNK21B1/2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK-46, JNK-55, Jun kinase, MAP kinase 10, MAP kinase 8, MAP kinase 9, MAPK 10, MAPK 9, MAPK10, MAPK8, Mapk9, mitogen activated protein kinase 9, mitogen-activated protein kinase 9, OTTHUMP00000161542, OTTHUMP00000161543, p54a, p54-alpha, p54aSAPK, PRKM8, PRKM9, protein kinase, mitogen-activated 9, SAPK, SAPK1, SAPK1a, SAPK1c, SAPK-alpha, stress activated protein kinase alpha II, stress-activated protein kinase 1a, Stress-activated protein kinase JNK2
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
26420, 50658, 5601
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: DNA-PK
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P78527, P97313
Gene Symbols: PRKDC
Immunogen: Synthetic peptide within Human DNA PKcs aa 4062-4109
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: ChIP Assay, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SC57-08
Conjugate: Unconjugated
Gene: PRKDC
Gene Alias: AI326420, AU019811, DNA-dependent protein kinase catalytic subunit, DNAPDcs, DNAPK, DNA-PK catalytic subunit, DNA-PKcs, DNPK1, DOXNPH, doxorubicin nephropathy, dxnph, hyper-radiosensitivity of murine scid mutation, complementing 1, HYRC, HYRC1, I79_017613, IMD26, p350, p460, Prkdc, protein kinase, DNA activated, catalytic polypeptide, protein kinase, DNA-activated, catalytic polypeptide, scid, severe combined immunodeficiency, slip, Xrcc7
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 19090, 360748, 5591
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
DNA-PK
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P78527, P97313
Gene Symbols:
PRKDC
Immunogen:
Synthetic peptide within Human DNA PKcs aa 4062-4109
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
ChIP Assay, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SC57-08
Conjugate:
Unconjugated
Gene:
PRKDC
Gene Alias:
AI326420, AU019811, DNA-dependent protein kinase catalytic subunit, DNAPDcs, DNAPK, DNA-PK catalytic subunit, DNA-PKcs, DNPK1, DOXNPH, doxorubicin nephropathy, dxnph, hyper-radiosensitivity of murine scid mutation, complementing 1, HYRC, HYRC1, I79_017613, IMD26, p350, p460, Prkdc, protein kinase, DNA activated, catalytic polypeptide, protein kinase, DNA-activated, catalytic polypeptide, scid, severe combined immunodeficiency, slip, Xrcc7
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
19090, 360748, 5591
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid