PIMA542904
MST2 Recombinant Rabbit Monoclonal Antibody (5J1I4), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA542904-Each-of-1 | In Stock | ₹ 44,020.62 |
PIMA542904 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,020.62
GST (18%): ₹ 7,923.712
Total Price: ₹ 51,944.332
Antigen
MST2
Classification
Recombinant Monoclonal
Concentration
0.38 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q13188, Q9JI10
Gene Symbols
STK3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human STK3/MST2 (Q13188).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
5J1I4
Conjugate
Unconjugated
Gene
STK3
Gene Alias
0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
56274, 6788
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Positive test controls include: HeLa, 293T, PC-12, A-549, Mouse lung
- The target is usually found in the following locations: Cytoplasm, Nucleus
- Immunogen sequence: MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand
- STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation
- It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
Compare Similar Items
Show Difference
Antigen: MST2
Classification: Recombinant Monoclonal
Concentration: 0.38 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q13188, Q9JI10
Gene Symbols: STK3
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human STK3/MST2 (Q13188).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: 5J1I4
Conjugate: Unconjugated
Gene: STK3
Gene Alias: 0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 56274, 6788
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
MST2
Classification:
Recombinant Monoclonal
Concentration:
0.38 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q13188, Q9JI10
Gene Symbols:
STK3
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human STK3/MST2 (Q13188).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
5J1I4
Conjugate:
Unconjugated
Gene:
STK3
Gene Alias:
0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
56274, 6788
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: SRC1
Classification: Recombinant Monoclonal
Concentration: 1.55 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q15788
Gene Symbols: NCOA1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 400-750 of human KAT13A / SRC1 (Q15788).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunoprecipitation, Western Blot
Clone: 3S4C6
Conjugate: Unconjugated
Gene: NCOA1
Gene Alias: ASV; bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; c-SRC; F-SRC-1; Hin-2 protein; KAT13A; mNRC-1; NCOA1; NCoA-1; Nuclear receptor coactivator 1; nuclear receptor coactivator protein 1; p60-Src; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; Src1; SRC-1; SRC-1 (-Q); SRC-a/NCoA-1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 8648
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
SRC1
Classification:
Recombinant Monoclonal
Concentration:
1.55 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q15788
Gene Symbols:
NCOA1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 400-750 of human KAT13A / SRC1 (Q15788).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunoprecipitation, Western Blot
Clone:
3S4C6
Conjugate:
Unconjugated
Gene:
NCOA1
Gene Alias:
ASV; bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; c-SRC; F-SRC-1; Hin-2 protein; KAT13A; mNRC-1; NCOA1; NCoA-1; Nuclear receptor coactivator 1; nuclear receptor coactivator protein 1; p60-Src; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; Src1; SRC-1; SRC-1 (-Q); SRC-a/NCoA-1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
8648
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: FUBP1
Classification: Recombinant Monoclonal
Concentration: 0.39 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q32PX7, Q91WJ8, Q96AE4
Gene Symbols: FUBP1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 545-644 of human FUBP1 (Q96AE4).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: 1G6X5
Conjugate: Unconjugated
Gene: FUBP1
Gene Alias: 9530027K12Rik; D3Ertd330e; DNA helicase V; EMBL:AAI07943.1, ECO:0000312; EMBL:AAI07943.1}; far upstream element (FUSE) binding protein 1; far upstream element (FUSE) binding protein 4; far upstream element binding protein 1; far upstream element-binding protein; far upstream element-binding protein 1; far upstream element-binding protein 1 {ECO:0000250; FBP; FBP {ECO:0000250; Fubp; Fubp1; fubp1 {ECO:0000312; Fubp4; FUSE binding protein 1; FUSE-binding protein 1; FUSE-binding protein 1 {ECO:0000250; hDH V; RGD:1591892}; UniProtKB:Q96AE4, ECO:0000312; UniProtKB:Q96AE4}
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 51886, 654496, 8880
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
FUBP1
Classification:
Recombinant Monoclonal
Concentration:
0.39 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q32PX7, Q91WJ8, Q96AE4
Gene Symbols:
FUBP1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 545-644 of human FUBP1 (Q96AE4).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
1G6X5
Conjugate:
Unconjugated
Gene:
FUBP1
Gene Alias:
9530027K12Rik; D3Ertd330e; DNA helicase V; EMBL:AAI07943.1, ECO:0000312; EMBL:AAI07943.1}; far upstream element (FUSE) binding protein 1; far upstream element (FUSE) binding protein 4; far upstream element binding protein 1; far upstream element-binding protein; far upstream element-binding protein 1; far upstream element-binding protein 1 {ECO:0000250; FBP; FBP {ECO:0000250; Fubp; Fubp1; fubp1 {ECO:0000312; Fubp4; FUSE binding protein 1; FUSE-binding protein 1; FUSE-binding protein 1 {ECO:0000250; hDH V; RGD:1591892}; UniProtKB:Q96AE4, ECO:0000312; UniProtKB:Q96AE4}
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
51886, 654496, 8880
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: NEDD4L
Classification: Recombinant Monoclonal
Concentration: 0.75 mg/mL
Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q96PU5
Gene Symbols: NEDD4L
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 876-975 of human NEDD4L (Q96PU5).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: 3W9J2
Conjugate: Unconjugated
Gene: NEDD4L
Gene Alias: 1300012C07Rik; E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; KIAA0439; NEDD4; NEDD4 like E3 ubiquitin protein ligase; NEDD4.2; Nedd4-2; nedd4b; NEDD4L; NEDL3; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4b; neural precursor cell expressed, developmentally down-regulated gene 4-like; RSP5; ubiquitin-protein ligase Nedd4-2; ubiquitin-protein ligase Rsp5; Unknown (protein for IMAGE:7986262)
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23327
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
NEDD4L
Classification:
Recombinant Monoclonal
Concentration:
0.75 mg/mL
Formulation:
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q96PU5
Gene Symbols:
NEDD4L
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 876-975 of human NEDD4L (Q96PU5).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
3W9J2
Conjugate:
Unconjugated
Gene:
NEDD4L
Gene Alias:
1300012C07Rik; E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; KIAA0439; NEDD4; NEDD4 like E3 ubiquitin protein ligase; NEDD4.2; Nedd4-2; nedd4b; NEDD4L; NEDL3; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4b; neural precursor cell expressed, developmentally down-regulated gene 4-like; RSP5; ubiquitin-protein ligase Nedd4-2; ubiquitin-protein ligase Rsp5; Unknown (protein for IMAGE:7986262)
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23327
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid