H7416
Interleukin-6 human
IL-6, recombinant, expressed in HEK 293 cells, suitable for cell culture
Manufacturer: Sigma Aldrich
Synonym(S): IL-6
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 μG | H7416-10-μG | In Stock | ₹ 29,093.10 |
H7416 - 10 μG
In Stock
Quantity
1
Base Price: ₹ 29,093.10
GST (18%): ₹ 5,236.758
Total Price: ₹ 34,329.858
biological source
human
Quality Level
100
recombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤2.0 ng/mL ED50
quality
endotoxin tested
mol wt
dimer 26-30 kDa (glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
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Description
- General description: The IL6 (interleukin-6) gene is mapped to human chromosome 7p15.3.[1] All the members of IL6 family have membrane glycoprotein gp130 as a common receptor.[2] IL6 (interleukin-6) induces B-cell differentiation and is a primary regulator of inflammation.[3]
- Application: Interleukin-6 human has been used to check its role in breast cancer metastasis.[4] It has also been used for evaluating its role in D5HS tumor sphere formation.[5]
- Biochem/physiol Actions: IL6 regulates tumor proliferation and inhibits apoptosis.[3] It contributes to the disease progression of coronary artery disease.[6]
- Preparation Note: Human IL-6, expressed in human 293 cells, is a glycosylated monomer with an apparent molecular mass of 26-30 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
- Analysis Note: The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
SAFETY INFORMATION
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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biological source: human
Quality Level: 100
recombinant: expressed in HEK 293 cells
Assay: ≥95% (SDS-PAGE)
form: lyophilized powder
potency: ≤2.0 ng/mL ED50
quality: endotoxin tested
mol wt: dimer 26-30 kDa (glycosylated)
packaging: pkg of 10 μg
technique(s): cell culture | mammalian: suitable
biological source:
human
Quality Level:
100
recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
form:
lyophilized powder
potency:
≤2.0 ng/mL ED50
quality:
endotoxin tested
mol wt:
dimer 26-30 kDa (glycosylated)
packaging:
pkg of 10 μg
technique(s):
cell culture | mammalian: suitable
biological source: __
Quality Level: 100
recombinant: __
Assay: ≥99%
form: __
potency: __
quality: __
mol wt: __
packaging: __
technique(s): __
biological source:
__
Quality Level:
100
recombinant:
__
Assay:
≥99%
form:
__
potency:
__
quality:
__
mol wt:
__
packaging:
__
technique(s):
__
biological source: plant
Quality Level: 200
recombinant: __
Assay: __
form: powder
potency: __
quality: __
mol wt: ~86 kDa
packaging: __
technique(s): __
biological source:
plant
Quality Level:
200
recombinant:
__
Assay:
__
form:
powder
potency:
__
quality:
__
mol wt:
~86 kDa
packaging:
__
technique(s):
__
biological source: plant
Quality Level: 200
recombinant: __
Assay: __
form: powder
potency: __
quality: __
mol wt: ~86 kDa
packaging: __
technique(s): __
biological source:
plant
Quality Level:
200
recombinant:
__
Assay:
__
form:
powder
potency:
__
quality:
__
mol wt:
~86 kDa
packaging:
__
technique(s):
__