Irisin

Description

• General description: Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5).[1][2] FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung.[2] The gene encoding irisin is mapped to human chromosome 1p35.1.[3]
• Biochem/physiol Actions: Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure.[1][2] It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure.[1] Irisin is always associated with beneficial responses of exercise on cellular metabolism.[2] In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.[4]
• Physical form: Lyophilized from PBS.
• Reconstitution: Reconstitute with 100 μL deionized water.
• Other Notes: Irisin (human, aa 16-127 /mouse, aa 29-140) is Flag-tagged at the N-terminus. Irisin has 100% identity betwen mouse, rat, monkey and human.
• Legal Information: FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany