Description

• General description: Phosphatidylserine (PS) is an acidic phospholipid enriched in human cerebral cortex.[1] It is abundant in the inner leaflet of the plasma membrane in neural tissues.[2] NBD PS is a fluorescently labeled phospholipid with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the headgroup of PS.[3]
• Application: 18:1-06:0 NBD PS or 1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt) may be used as a marker to determine the aminophospholipid transferase activity[4] and in large unilammelar vesicles (LUVs) to investigate the role of phosphatidylinositol 4,5-bisphosphate (PIP2).[5]
• Biochem/physiol Actions: Phosphatidylserine (PS) is involved in the regulation of many enzymes and structural components.[6] It supports neuronal survival, neurite growth and synaptogenesis.[1] It is associated with cognitive disability in Alzheimer′s disease.[7]
• Packaging: 5 mL Amber Glass Screw Cap Vial (810194P-1mg)