E4630
Ethambutol dihydrochloride
antimycobacterial
Manufacturer: Sigma Aldrich
CAS Number: 1070-11-7
Synonym(S): Ethambutol, Ethambutol HCL, 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride, Emb
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 G | E4630-25-G | In Stock | ₹ 22,010.00 |
| 100 G | E4630-100-G | In Stock | ₹ 37,510.00 |
E4630 - 25 G
In Stock
Quantity
1
Base Price: ₹ 22,010.00
GST (18%): ₹ 3,961.80
Total Price: ₹ 25,971.80
Quality Level
200
form
powder
optical activity
[α]25/D 6.0 to 6.7°, c = 10 in water
color
white
solubility
H2O: 50 mg/mL
antibiotic activity spectrum
mycobacteria
Mode of action
cell wall synthesis | interferes
SMILES string
CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
InChI
1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChI key
AUAHHJJRFHRVPV-BZDVOYDHSA-N
Other Options
Related Products
Description
- Application: Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.
- Biochem/physiol Actions: Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
Show Difference
Quality Level: 200
form: powder
optical activity: [α]25/D 6.0 to 6.7°, c = 10 in water
color: white
solubility: H2O: 50 mg/mL
antibiotic activity spectrum: mycobacteria
Mode of action: cell wall synthesis | interferes
SMILES string: CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
InChI: 1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChI key: AUAHHJJRFHRVPV-BZDVOYDHSA-N
Quality Level:
200
form:
powder
optical activity:
[α]25/D 6.0 to 6.7°, c = 10 in water
color:
white
solubility:
H2O: 50 mg/mL
antibiotic activity spectrum:
mycobacteria
Mode of action:
cell wall synthesis | interferes
SMILES string:
CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
InChI:
1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChI key:
AUAHHJJRFHRVPV-BZDVOYDHSA-N
Quality Level: 200
form: powder or crystals
optical activity: __
color: white to off-white
solubility: __
antibiotic activity spectrum: Gram-positive bacteriafungi
Mode of action: cell membrane | interferescell wall synthesis | interferesenzyme | inhibits
SMILES string: O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI: 1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key: DDXORDQKGIZAME-UHFFFAOYSA-N
Quality Level:
200
form:
powder or crystals
optical activity:
__
color:
white to off-white
solubility:
__
antibiotic activity spectrum:
Gram-positive bacteriafungi
Mode of action:
cell membrane | interferescell wall synthesis | interferesenzyme | inhibits
SMILES string:
O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI:
1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key:
DDXORDQKGIZAME-UHFFFAOYSA-N
Quality Level: 200
form: powder or crystals
optical activity: __
color: white to off-white
solubility: __
antibiotic activity spectrum: Gram-positive bacteriafungi
Mode of action: cell membrane | interferescell wall synthesis | interferesenzyme | inhibits
SMILES string: O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI: 1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key: DDXORDQKGIZAME-UHFFFAOYSA-N
Quality Level:
200
form:
powder or crystals
optical activity:
__
color:
white to off-white
solubility:
__
antibiotic activity spectrum:
Gram-positive bacteriafungi
Mode of action:
cell membrane | interferescell wall synthesis | interferesenzyme | inhibits
SMILES string:
O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI:
1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key:
DDXORDQKGIZAME-UHFFFAOYSA-N
Quality Level: 200
form: powder
optical activity: __
color: __
solubility: __
antibiotic activity spectrum: __
Mode of action: __
SMILES string: __
InChI: __
InChI key: __
Quality Level:
200
form:
powder
optical activity:
__
color:
__
solubility:
__
antibiotic activity spectrum:
__
Mode of action:
__
SMILES string:
__
InChI:
__
InChI key:
__