SML1278

Geldanamycin Ready Made Solution

1 mg/mL, from Streptomyces hygroscopicus

Manufacturer: Sigma Aldrich

CAS Number: 30562-34-6

Synonym(S): 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)

Select a Size

Pack Size SKU Availability Price
1 ML SML1278-1-ML In Stock ₹ 16,705.50

SML1278 - 1 ML

₹ 16,705.50

In Stock

Quantity

1

Base Price: ₹ 16,705.50

GST (18%): ₹ 3,006.99

Total Price: ₹ 19,712.49

biological source

Streptomyces hygroscopicus

Quality Level

200

form

DMSO solution

storage condition

protect from light

concentration

1 mg/mL

antibiotic activity spectrum

neoplastics

Mode of action

enzyme | inhibits

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

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Description

  • General description: Chemical structure: benzenoid
  • Application: Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.[1]
  • Biochem/physiol Actions: Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.[2]

SAFETY INFORMATION

WGK

WGK 1

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C

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biological source:
Streptomyces hygroscopicus

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200

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DMSO solution

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protect from light

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1 mg/mL

antibiotic activity spectrum:
neoplastics

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enzyme | inhibits

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dry ice

storage temp.:
−20°C

InChI:
1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

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1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m1./s1

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1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)

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1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3