929379
Opto-thalidomide-O-acetamide-C4-NH2 hydrochloride
Manufacturer: Sigma Aldrich
Synonym(S): 4,5-Dimethoxy-2-nitrobenzyl 3-(4-(2-((4-aminobutyl)amino)-2-oxoethoxy)-1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidine-1-carboxylate hydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 929379-50-MG | In Stock | ₹ 41,881.93 |
929379 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 41,881.93
GST (18%): ₹ 7,538.747
Total Price: ₹ 49,420.677
ligand
thalidomide
Quality Level
100
form
powder
functional group
amine
storage temp.
2-8°C
SMILES string
COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(OCC(NCCCCN)=O)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O.Cl
Related Products
Description
- Application: Protein degrader building block Opto-thalidomide-O-acetamide-C4-NH2 hydrochloride enables the synthesis of molecules for light-induced targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Protein Degrader Building Blocks
- Other Notes: Targeted Protein Degradation by Small Molecules Light-induced control of protein destruction by opto-PROTAC Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
ligand: thalidomide
Quality Level: 100
form: powder
functional group: amine
storage temp.: 2-8°C
SMILES string: COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(OCC(NCCCCN)=O)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O.Cl
ligand:
thalidomide
Quality Level:
100
form:
powder
functional group:
amine
storage temp.:
2-8°C
SMILES string:
COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(OCC(NCCCCN)=O)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O.Cl
ligand: pomalidomide
Quality Level: 100
form: solid or liquid
functional group: __
storage temp.: 2-8°C
SMILES string: O=C1C2=C(C(NCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)=CC=C2)C(N1C3C(NC(CC3)=O)=O)=O
ligand:
pomalidomide
Quality Level:
100
form:
solid or liquid
functional group:
__
storage temp.:
2-8°C
SMILES string:
O=C1C2=C(C(NCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)=CC=C2)C(N1C3C(NC(CC3)=O)=O)=O
ligand: pomalidomide
Quality Level: 100
form: powder
functional group: amine
storage temp.: 2-8°C
SMILES string: COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(NCCN)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O
ligand:
pomalidomide
Quality Level:
100
form:
powder
functional group:
amine
storage temp.:
2-8°C
SMILES string:
COC1=CC(COC(N2C(CCC(N3C(C4=CC=CC(NCCN)=C4C3=O)=O)C2=O)=O)=O)=C(C=C1OC)[N+]([O-])=O
ligand: pomalidomide
Quality Level: 100
form: powder
functional group: __
storage temp.: 2-8°C
SMILES string: O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CCNCC4)C=C31)=O
ligand:
pomalidomide
Quality Level:
100
form:
powder
functional group:
__
storage temp.:
2-8°C
SMILES string:
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CCNCC4)C=C31)=O