7110969
Tocris Bioscience™ GNF 7
Ras signaling inhibitor; inhibits Ack1 and GCK
Manufacturer: Fischer Scientific
CAS Number: 839706-07-9
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Chemical Name or Material
Ras GTPase Inhibitors
Target
Small G Protein Inhibitors
Formula Weight
547.53
CAS
839706-07-9
Molecular Formula
C28H24F3N7O2
Purity
>98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ GNF 7 | Fischer Scientific | ₹ 22,093.36 | |
| | Tocris Bioscience™ GNF 7 | Fischer Scientific | ₹ 92,193.32 | |
 | Medchemexpress LLC HY-10943 5mg Medchemexpress, GNF-7 CAS:839706-07-9 Purity:>98% | Medchemexpress LLC | ₹ 10,092.60 | |
 | eMolecules Medchem Express / GNF-7 / 5mg / 446259574 / HY-10943 / / 839706-07-9 / MFCD18251569 / 547.542 / C28H24F3N7O2 | eMolecules | ₹ 14,149.22 | |
 | 839706-07-9 | BenzaMide, N-[3-[1,4-dihydro-1-Methyl-7-[(6-Methyl-3-pyridinyl)aMino]-2-oxopyriMido[4,5-d]pyriMidin-3(2H)-yl]-4-Methylphenyl]-3-(trifluoroMethyl)- | A2B Chem | ₹ 2,581.00 - ₹ 14,418.00 |
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Description
- GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T
- GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK)
- GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells
- It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: Ras GTPase Inhibitors
Target: Small G Protein Inhibitors
Formula Weight: 547.53
CAS: 839706-07-9
Molecular Formula: C28H24F3N7O2
Purity: >98%
Chemical Name or Material:
Ras GTPase Inhibitors
Target:
Small G Protein Inhibitors
Formula Weight:
547.53
CAS:
839706-07-9
Molecular Formula:
C28H24F3N7O2
Purity:
>98%
Chemical Name or Material: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Target: Cyclin-dependent Kinase Inhibitors
Formula Weight: 453.45
CAS: 1883548-83-1
Molecular Formula: C22H32N6.2HCl
Purity: >99%
Chemical Name or Material:
N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Target:
Cyclin-dependent Kinase Inhibitors
Formula Weight:
453.45
CAS:
1883548-83-1
Molecular Formula:
C22H32N6.2HCl
Purity:
>99%
Chemical Name or Material: (5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2,3-dimethyl-4H-imidazol-4-one
Target: Light-up Aptamers
Formula Weight: 252.22
CAS: 1241390-29-3
Molecular Formula: C12H10F2N2O2
Purity: >98%
Chemical Name or Material:
(5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2,3-dimethyl-4H-imidazol-4-one
Target:
Light-up Aptamers
Formula Weight:
252.22
CAS:
1241390-29-3
Molecular Formula:
C12H10F2N2O2
Purity:
>98%
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