7145995

Tocris Bioscience™ CP 43

Potent TAOK inhibitor

Manufacturer: Fischer Scientific

CAS Number: 850467-66-2

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Chemical Name or Material

N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1′-biphenyl]-4-carboxamide

CAS

850467-66-2

Molecular Formula

C25H24N2O2

Purity

98%

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Description

  • Potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively)
  • Inhibits TAOK phosphorylation and activation of JNK in vitro
  • Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line
  • Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

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7145995

Potent TAOK inhibitor...


Chemical Name or Material:
N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1′-biphenyl]-4-carboxamide

CAS:
850467-66-2

Molecular Formula:
C25H24N2O2

Purity:
98%

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Chemical Name or Material:
2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid

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1256341-22-6

Molecular Formula:
C28H39N04

Purity:
98%

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Chemical Name or Material:
4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid

CAS:
1073612-91-5

Molecular Formula:
C19H12F3NO3S2

Purity:
98%

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For use in research applications....


Chemical Name or Material:
__

CAS:
3239-45-0

Molecular Formula:
C12H16F3N.HCl

Purity:
__