7237009
Tocris Bioscience™ WS 383
Potent, selective and reversible DCN1-UBC12 interaction inhibitor
Manufacturer: Fischer Scientific
CAS Number: 2247544-02-9
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Chemical Name or Material
5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4 ]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1 H-tetrazole-1-ethanamine hydrochloride
Target
Ubiquitin Ligase (E3) Inhibitors
Purity
0.98
CAS
2247544-02-9
Molecular Formula
C18H20ClN9S2.HCl
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ WS 383 | Fischer Scientific | ₹ 20,842.42 | |
| | Tocris Bioscience™ WS 383 | Fischer Scientific | ₹ 87,835.90 | |
 | WS-383 | ChemScene | ₹ 9,411.60 - ₹ 98,394.00 |
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Description
- WS 383 is a potent and reversible DCN1-UBC12 interaction inhibitor (IC50 = 11 nM)
- The compound displays selectivity for DCN1-UBC12 over inhibition of a panel of kinases
- including Bruton's tyrosine kinase (BTK), cyclin-dependent kinases (CDKs) and epidermal growth factor receptor (EGFR)
- In vitro , WS 383 selectively inhibits cullin-3 neddylation over other cullins, and induces accumulation of p21, p27 and NRF2.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4 ]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1 H-tetrazole-1-ethanamine hydrochloride
Target: Ubiquitin Ligase (E3) Inhibitors
Purity: 0.98
CAS: 2247544-02-9
Molecular Formula: C18H20ClN9S2.HCl
Chemical Name or Material:
5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4 ]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1 H-tetrazole-1-ethanamine hydrochloride
Target:
Ubiquitin Ligase (E3) Inhibitors
Purity:
0.98
CAS:
2247544-02-9
Molecular Formula:
C18H20ClN9S2.HCl
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