7237097
Tocris Bioscience™ NS 383
ASIC blocker; active in vivo
Manufacturer: Fischer Scientific
CAS Number: 309711-59-9
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Chemical Name or Material
8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1 H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
CAS
309711-59-9
Target
Acid-sensing Ion Channel Blockers
Molecular Formula
C19H19N3O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ NS 383 | Fischer Scientific | ₹ 15,482.94 | |
| | Tocris Bioscience™ NS 383 | Fischer Scientific | ₹ 64,512.24 |
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Description
- NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3)
- Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3)
- Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1 H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
CAS: 309711-59-9
Target: Acid-sensing Ion Channel Blockers
Molecular Formula: C19H19N3O2
Chemical Name or Material:
8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1 H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
CAS:
309711-59-9
Target:
Acid-sensing Ion Channel Blockers
Molecular Formula:
C19H19N3O2
Chemical Name or Material: Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate
CAS: 1477949-42-0
Target: Class II Histone Deacetylases Inhibitors
Molecular Formula: C15H22N2O3
Chemical Name or Material:
Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate
CAS:
1477949-42-0
Target:
Class II Histone Deacetylases Inhibitors
Molecular Formula:
C15H22N2O3
Chemical Name or Material: 11-(4-Methyl-1-piperazinyl)-5 H-dibenzo[b,e][1,4 ]diazepine
CAS: 1977-07-07 00:00:00
Target: DREADD Activators
Molecular Formula: C18H20N4
Chemical Name or Material:
11-(4-Methyl-1-piperazinyl)-5 H-dibenzo[b,e][1,4 ]diazepine
CAS:
1977-07-07 00:00:00
Target:
DREADD Activators
Molecular Formula:
C18H20N4
Chemical Name or Material: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
CAS: 2369979-68-8
Target: DREADD Activators
Molecular Formula: C19H20ClFN4
Chemical Name or Material:
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
CAS:
2369979-68-8
Target:
DREADD Activators
Molecular Formula:
C19H20ClFN4