Invitrogen™ Anti-Human Foxp3 Staining Set PE, eBioscience™

Description

• This Anti-Human Foxp3 Staining Set contains the buffers and monoclonal antibody necessary to successfully stain and identify Foxp3 cells
• The PCH101 monoclonal antibody reacts with the amino terminus of human Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2
• Foxp3 is a 49-55 kDa protein and a member of the forkhead/winged-helix family of transcription factors
• It was identified as the gene responsible for the X-linked lymphoproliferative disease observed in scurfy (sf) mice and in the human disorder, X-linked autoimmunity-allergic dysregulation syndrome (XLAAD)
• Constitutive expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg), and ectopic expression of Foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells
• The PCH101 antibody crossreacts with rhesus, chimpanzee, and cynomolgus Foxp3 PCH101 recognizes a different epitope of Foxp3 than clones 236A/E7 and 150D/E4
• Isotype: IgG2a, kappa Laser: Blue Laser Excitation/Emission: 488/575 nm Reported Applications Intracellular Staining followed by Flow Cytometric Analysis