4555619

p170/p-Glycoprotein/MDR Ab-2 Mouse Monoclonal Antibody, Epredia™

Ensure accurate, reproducible results with the Epredia™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody.

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

p170/p-Glycoprotein/MDR Ab-2

Applications

Immunofluorescence, Western Blot

Conjugate

Unconjugated

Host Species

Mouse

Research Discipline

Cancer and Tumor Biology

Immunogen

Human and hamster drug-resistant viable cells followed by crude plasma membranes

Primary or Secondary

Primary

Clone

F4

Classification

Monoclonal

Form

Concentrated

Regulatory Status

RUO

Target Species

Hamster, Human

Isotype

IgG1

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Description

  • Multi-drug resistance(MDR) associated p-glycoprotein (p170) causes resistance to various drugs in a number of cancer patients
  • It exists in a soluble and membrane associated form
  • Soluble P-glycoprotein is detected in extracellular fluids of cancer patients, such as malignant ascites and serum
  • The Mr of soluble P-glycoprotein is the same as that of membrane bound P-glycoprotein
  • Host Species: Mouse Clone: F4 Isotype: IgG1 Species Reactivity: Human, Chinese Hamster
  • Does not react with mouse
  • Others not known
  • Epitope: Extracellular amino terminal half
  • This epitope is resistant to formalin fixation and periodate oxidation and is different from those of other commonly known MAbs to p-glycoprotein, such as C219, JSB-1, and MRK16, which recognize an intracellular and extracellular epitope of p-glycoprotein, respectively
  • Immunogen: Human and hamster drug-resistant viable cells followed by crude plasma membranes Molecular Weight: 170kDa Positive Control: Drug-resistant cells, Kidney or breast CA Cellular Localization: Membrane Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunofluorescence Flow Cytometry (Fixed cells only) Note: USA: RUO; Int'l: RUO

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Antigen:
p170/p-Glycoprotein/MDR Ab-2

Applications:
Immunofluorescence, Western Blot

Conjugate:
Unconjugated

Host Species:
Mouse

Research Discipline:
Cancer and Tumor Biology

Immunogen:
Human and hamster drug-resistant viable cells followed by crude plasma membranes

Primary or Secondary:
Primary

Clone:
F4

Classification:
Monoclonal

Form:
Concentrated

Regulatory Status:
RUO

Target Species:
Hamster, Human

Isotype:
IgG1

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4555622

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Antigen:
p21superscriptWAF1superscript Ab-11

Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Conjugate:
__

Host Species:
Mouse

Research Discipline:
Cell Cycle

Immunogen:
Full length human recombinant p21 protein

Primary or Secondary:
Primary

Clone:
CP74

Classification:
Monoclonal

Form:
Concentrated

Regulatory Status:
RUO

Target Species:
Human, Rat

Isotype:
IgG2b

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Antigen:
p21WAF1 Ab-6

Applications:
Immunofluorescence, Western Blot

Conjugate:
Unconjugated

Host Species:
Mouse

Research Discipline:
Cancer and Tumor Biology

Immunogen:
Human recombinant p21 protein

Primary or Secondary:
Primary

Clone:
HJ21; same as WA-1

Classification:
Monoclonal

Form:
Concentrated

Regulatory Status:
RUO

Target Species:
Human, Rat

Isotype:
IgG1

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4555626

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Antigen:
p300/CBP (CREB-Binding Protein) Ab-1

Applications:
Immunofluorescence, Immunohistochemistry (Paraffin)

Conjugate:
__

Host Species:
Mouse

Research Discipline:
Transcription Regulation

Immunogen:
E1A affinity purified p300 protein

Primary or Secondary:
Primary

Clone:
NM11

Classification:
Monoclonal

Form:
__

Regulatory Status:
RUO

Target Species:
Human, Mink, Mouse, Non-human Primate, Rat

Isotype:
IgG2b κ