4556436
Pds1 Ab-1 Mouse Monoclonal Antibody, Epredia™
Provide accurate, reproducible results with the Epredia™ Pds1 Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Fischer Scientific
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Antigen
Pds1 Ab-1
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2a κ
Clone
DCS-280
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cancer and Tumor Biology
Immunogen
Human recombinant full length Pds1 protein
Primary or Secondary
Primary
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Description
- Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways
- Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together
- Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle
- Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry
- Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase
- In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase
- Host Species: Mouse Clone: DCS-280 Isotype: IgG2a/κ Species Reactivity: Human
- Others not known
- Epitope: Not determined Immunogen: Human recombinant full-length Pds1 protein Molecular Weight: 42kDa Positive Control: HeLa cells, Tonsil Cellular Localization: Nuclear Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting (Not verified) Note: USA: RUO; Int'l: RUO
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Antigen: Pds1 Ab-1
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2a κ
Clone: DCS-280
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cancer and Tumor Biology
Immunogen: Human recombinant full length Pds1 protein
Primary or Secondary: Primary
Antigen:
Pds1 Ab-1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ
Clone:
DCS-280
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cancer and Tumor Biology
Immunogen:
Human recombinant full length Pds1 protein
Primary or Secondary:
Primary
Antigen: Perforin Ab-2
Applications: Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Regulatory Status: IVD
Target Species: Human
Isotype: IgG1
Clone: 5B10
Classification: Monoclonal
Host Species: Mouse
Research Discipline: T-Cell
Immunogen: Recombinant protein corresponding to C-terminal region of human perforin
Primary or Secondary: Primary
Antigen:
Perforin Ab-2
Applications:
Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Regulatory Status:
IVD
Target Species:
Human
Isotype:
IgG1
Clone:
5B10
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
T-Cell
Immunogen:
Recombinant protein corresponding to C-terminal region of human perforin
Primary or Secondary:
Primary
Antigen: Perforin Ab-2
Applications: Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Regulatory Status: IVD
Target Species: Human
Isotype: IgG1
Clone: 5B10
Classification: Monoclonal
Host Species: Mouse
Research Discipline: T-Cell
Immunogen: Recombinant protein corresponding to C-terminal region of human perforin
Primary or Secondary: Primary
Antigen:
Perforin Ab-2
Applications:
Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Regulatory Status:
IVD
Target Species:
Human
Isotype:
IgG1
Clone:
5B10
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
T-Cell
Immunogen:
Recombinant protein corresponding to C-terminal region of human perforin
Primary or Secondary:
Primary
Antigen: __
Applications: __
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Target Species: __
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Applications:
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Isotype:
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Clone:
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Classification:
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Immunogen:
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