5349355
MilliporeSigma™ anti-CD8a PE, Clone: 53-6.7,
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD8a
Applications
Flow Cytometry
Conjugate
PE
Host Species
Rat
Research Discipline
Inflammation, Immunology
Formulation
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols
CD8a
Isotype
IgG2a κ
Purification Method
Purified by size-exclusion chromatography
Clone
53-6.7
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Accession No.
P01731
Immunogen
Proprietary immunogen
Primary or Secondary
Primary
Content And Storage
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
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Description
- Specifically detects CD8a Clone: 53-6.7 in Mouse samples, and it is validated for Flow Cytometry The 53-6.7 antibody reacts with the 32-34kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha
- CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta
- CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules
- The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions
- CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.
Compare Similar Items
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Antigen: CD8a
Applications: Flow Cytometry
Conjugate: PE
Host Species: Rat
Research Discipline: Inflammation, Immunology
Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols: CD8a
Isotype: IgG2a κ
Purification Method: Purified by size-exclusion chromatography
Clone: 53-6.7
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Accession No.: P01731
Immunogen: Proprietary immunogen
Primary or Secondary: Primary
Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Antigen:
CD8a
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rat
Research Discipline:
Inflammation, Immunology
Formulation:
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols:
CD8a
Isotype:
IgG2a κ
Purification Method:
Purified by size-exclusion chromatography
Clone:
53-6.7
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Accession No.:
P01731
Immunogen:
Proprietary immunogen
Primary or Secondary:
Primary
Content And Storage:
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Antigen: CD8a
Applications: Flow Cytometry
Conjugate: PerCP-Cyanine5.5
Host Species: Rat
Research Discipline: Inflammation, Immunology
Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols: CD8a
Isotype: IgG2a κ
Purification Method: Purified by size-exclusion chromatography
Clone: 53-6.7
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Accession No.: P01731
Immunogen: Proprietary immunogen
Primary or Secondary: Primary
Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Antigen:
CD8a
Applications:
Flow Cytometry
Conjugate:
PerCP-Cyanine5.5
Host Species:
Rat
Research Discipline:
Inflammation, Immunology
Formulation:
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols:
CD8a
Isotype:
IgG2a κ
Purification Method:
Purified by size-exclusion chromatography
Clone:
53-6.7
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Accession No.:
P01731
Immunogen:
Proprietary immunogen
Primary or Secondary:
Primary
Content And Storage:
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Antigen: CD8a
Applications: Flow Cytometry
Conjugate: Red Fluor 710
Host Species: Rat
Research Discipline: Inflammation, Immunology
Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols: CD8a
Isotype: __
Purification Method: Purified by size-exclusion chromatography
Clone: 53-6.7
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Accession No.: P01731
Immunogen: Proprietary immunogen
Primary or Secondary: Primary
Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Antigen:
CD8a
Applications:
Flow Cytometry
Conjugate:
Red Fluor 710
Host Species:
Rat
Research Discipline:
Inflammation, Immunology
Formulation:
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols:
CD8a
Isotype:
__
Purification Method:
Purified by size-exclusion chromatography
Clone:
53-6.7
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Accession No.:
P01731
Immunogen:
Proprietary immunogen
Primary or Secondary:
Primary
Content And Storage:
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Antigen: CD11b
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rat
Research Discipline: Inflammation, Immunology
Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols: Itgam
Isotype: IgG2b κ
Purification Method: Purified by size-exclusion chromatography
Clone: M1/70
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human, Mouse
Gene Accession No.: P05555
Immunogen: Proprietary immunogen
Primary or Secondary: Primary
Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Antigen:
CD11b
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rat
Research Discipline:
Inflammation, Immunology
Formulation:
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols:
Itgam
Isotype:
IgG2b κ
Purification Method:
Purified by size-exclusion chromatography
Clone:
M1/70
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human, Mouse
Gene Accession No.:
P05555
Immunogen:
Proprietary immunogen
Primary or Secondary:
Primary
Content And Storage:
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze