MilliporeSigma™ Adiponectin, Rabbit, Unlabeled, Polyclonal,

Description

• Adiponectin (UniProt Q15848; also known as 30kDa adipocyte complement-related protein, ACRP30, Adipocyte complement-related 30kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the ADIPOQ (also known as ACDC, ACRP30, ADPND, APM1, GBP28) gene (Gene ID 9370) in human
• Adipokines are adipose tissue-secreted factors that are involved in vascular function and metabolic disease
• While most adipokines are proinflammatory and directly responsible for the development of the chronic inflammatory state in obesity, adiponectin is an adipokine with anti-inflammatory and insulin-sensitizing properties
• Adiponectin mediates its biological activity via adiponection receptor proteins 1 and 2 (AdipoR1 and AdipoR2)
• Both AdipoR1 and AdipoR2 are reported to be ubiquitously expressed with the highest expression in skeletal muscle and liver, respectively
• Circulating adiponectin levels are reduced in obesity and type II diabetes, whereas weight loss elevates serum levels of adiponectin
• Likewise, adiponectin overexpression is reported to alleviate metabolic dysfunction independent of weight loss in both genetic and diet-induced animal models of obesity
• Aadiponectin deficiency is associated with various clinical cardiovascular disorders including myocardial infarction, peripheral artery disease, and endothelial dysfunction
• Adiponectin is produced with a signal peptide sequence (a.a
• 1-18 in human and rat sequence; a.a
• 1-17 in mouse), which is removed postranslationally to yield the mature protein with a collagen-like domain (a.a
• 42-107 in human and rat, a.a
• 45-110 in mouse) and a C1q domain (a.a
• 108-244 in human and rat, a.a
• 111-247 in mouse).