AB9566IMI
MilliporeSigma™ anti-OTX2, Polyclonal
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | AB9566IMI-Each-of-1 | In Stock | ₹ 42,676.47 |
AB9566IMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,676.47
GST (18%): ₹ 7,681.765
Total Price: ₹ 50,358.235
Antigen
OTX2
Classification
Polyclonal
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
OTX2
Immunogen
KLH-conjugated linear peptide corresponding to the internal region of human OTX2.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_758840
Target Species
Human
Applications
Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Gene Accession No.
P32243
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both spliced isoforms, as well as all five polymorphic forms of human OTX2 reported by UniProt (P32243). The immunogen sequence is about 78% conserved in OTX1, this polyclonal antibody may therefore recognize OTX1. However, OTX1 cross-reactivity has not been directly tested and confirmed. OTX2 is expressed earlier than OTX1 and therefore this antibody can be used to identify OTX2 during development.
Content And Storage
2°C to 8°C for one year
Related Products
Description
- Specifically detects OTX2 Clone: in Human samples, and it is validated for Immunohistochemistry, Western Blotting Homeobox protein OTX2 (UniProt P32243; also known as Orthodenticle homolog 2) is encoded by the OTX2 (also known as CPHD6, MCOPS5) gene (Gene ID 5015) in human
- OTX2 is a paired-type homeobox transcription factor that controls the expression of target genes by binding to regulatory regions containing the YTAATNN motifs
- Studies conducted in mice shows developmental stage-dependent expression pattern
- OTX2 is widely expressed in the epiblast, but becomes progressively regionalised during gastrulation to an anterior domain of the ectoderm (anterior neuroectoderm, ANE) that contains the precursor cells of the prosencephalon and the mesencephalon of the embryonic brain
- The precursor cells for the anterior visceral endoderm (AVE) fail to translocate from the distal site to the anterior region of the pre-gastrulation stage Otx2-knockout embryos
- The absence of the AVE, in turn, causes the loss of the source of morphogenetic signals for inducing neural differentiation of the ANE
- In addtion, OTX2 is shown to be essential in the anterior mesendoderm (AME) for the induction of anterior neural tissues and head formation
- OTX2 is reported to mediate the transcriptions of Dkk1 and Lhx1, loss of Otx2 in the AME results in the downregulation of Dkk1 and Lhx1.
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Antigen: OTX2
Classification: Polyclonal
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: OTX2
Immunogen: KLH-conjugated linear peptide corresponding to the internal region of human OTX2.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_758840
Target Species: Human
Applications: Immunohistochemistry, Western Blot
Conjugate: Unconjugated
Gene Accession No.: P32243
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with both spliced isoforms, as well as all five polymorphic forms of human OTX2 reported by UniProt (P32243). The immunogen sequence is about 78% conserved in OTX1, this polyclonal antibody may therefore recognize OTX1. However, OTX1 cross-reactivity has not been directly tested and confirmed. OTX2 is expressed earlier than OTX1 and therefore this antibody can be used to identify OTX2 during development.
Content And Storage: 2°C to 8°C for one year
Antigen:
OTX2
Classification:
Polyclonal
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
OTX2
Immunogen:
KLH-conjugated linear peptide corresponding to the internal region of human OTX2.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_758840
Target Species:
Human
Applications:
Immunohistochemistry, Western Blot
Conjugate:
Unconjugated
Gene Accession No.:
P32243
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with both spliced isoforms, as well as all five polymorphic forms of human OTX2 reported by UniProt (P32243). The immunogen sequence is about 78% conserved in OTX1, this polyclonal antibody may therefore recognize OTX1. However, OTX1 cross-reactivity has not been directly tested and confirmed. OTX2 is expressed earlier than OTX1 and therefore this antibody can be used to identify OTX2 during development.
Content And Storage:
2°C to 8°C for one year
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