ABN896
MilliporeSigma™ LDHA, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN896-Each-of-1 | In Stock | ₹ 42,676.47 |
ABN896 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,676.47
GST (18%): ₹ 7,681.765
Total Price: ₹ 50,358.235
Antigen
LDHA
Classification
Polyclonal
Conjugate
Unconjugated
Gene
LDHA, GSD11, PIG19
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal targeted epitope region is present in human LDHA spliced isoforms 1, 3, and 4, but absent from isoforms 2 and 5, reported by UniProt (P00338).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Immunofluorescence, Immunohistochemistry, Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P00338
Immunogen
KLH-conjugated linear peptide corresponding to a C-terminal region sequence of human LDHA.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_005557
Target Species
Human
Related Products
Description
- L-lactate dehydrogenase A chain (EC 1.1.1.27; UniProt P00338; also known as Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-A, LDH-M, Renal carcinoma antigen NY-REN-59) is encoded by the LDHA (also known as GSD11, PIG19) gene (Gene ID 3939) in human
- Originally described by Otto Warburg and now commonly known as the Warburg effect refers to the phenomenon that many tumor cells use aerobic glycolysis instead of mitochondrial respiration for energy production to support cell growth and proliferation
- Enzymes involved in the complex network of metabolic pathways are therefore being studied as potential targets for cancer treatment
- Lactate dehydrogenase (LDH) is a tetrameric enzyme composed of two different subunits, LDHA and LDHB, which can assemble into five different combinations (LDH1 is comprised of four LDHB subunits; LDH2 contains three LDHB and one LDHA subunit; LDH3 contains two LDHB and two LDHA subunits; LDH4 contains one LDHB and three LDHA subunits; LDH5 contains four LDHA subunits)
- LDHB is ubiquitously expressed and the predominant isoform in heart muscle, while LDHA is the predominant isoform in skeletal muscle and other highly glycolytic tissues
- LDH catalyzes the reversible conversion of pyruvate into lactate
- An upregulation of LDH therefore reduces the oxygen dependency and ensures an efficient anaerobic/glycolytic metabolism in tumor cells
- Upregulated LDHA has been observed in hepatocellular carcinoma, breast, pancreatic, and prostate cancers
- Inhibition of LDHA reduced cell malignant transformation and tumor formation
- Serum LDHB level is also reported to elevate in lung cancer patients and progressively increase with the clinical stage of non-small cell lung cancer (NSCLC).
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Antigen: LDHA
Classification: Polyclonal
Conjugate: Unconjugated
Gene: LDHA, GSD11, PIG19
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal targeted epitope region is present in human LDHA spliced isoforms 1, 3, and 4, but absent from isoforms 2 and 5, reported by UniProt (P00338).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P00338
Immunogen: KLH-conjugated linear peptide corresponding to a C-terminal region sequence of human LDHA.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_005557
Target Species: Human
Antigen:
LDHA
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
LDHA, GSD11, PIG19
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal targeted epitope region is present in human LDHA spliced isoforms 1, 3, and 4, but absent from isoforms 2 and 5, reported by UniProt (P00338).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Immunofluorescence, Immunohistochemistry, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P00338
Immunogen:
KLH-conjugated linear peptide corresponding to a C-terminal region sequence of human LDHA.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_005557
Target Species:
Human
Antigen: AXL (UFO)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: AXL, UFO
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody targets cytoplasmic C-terminal end region present in both spliced isoforms of human AXL (UFO) reported by UniProt (P30530). This antibody will not detect internalized portion, but not the extracellular portion of the receptor following its cleavage by ADAM10.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P30530
Immunogen: GST-tagged human AXL (UFO) C-terminal end fragment lacking most of the kinase domain sequence.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_068713
Target Species: Human
Antigen:
AXL (UFO)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
AXL, UFO
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody targets cytoplasmic C-terminal end region present in both spliced isoforms of human AXL (UFO) reported by UniProt (P30530). This antibody will not detect internalized portion, but not the extracellular portion of the receptor following its cleavage by ADAM10.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P30530
Immunogen:
GST-tagged human AXL (UFO) C-terminal end fragment lacking most of the kinase domain sequence.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_068713
Target Species:
Human
Antigen: BMP2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: BMP2, BMP2A
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody targets a region present in Prepro-, pro-, and mature human BMP2.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P12643
Immunogen: GST-tagged recombinant protein composed of the propeptide C-terminal region and the mature human BMP2 N-terminal region.
Quantity: 200 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001191
Target Species: Human
Antigen:
BMP2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
BMP2, BMP2A
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody targets a region present in Prepro-, pro-, and mature human BMP2.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P12643
Immunogen:
GST-tagged recombinant protein composed of the propeptide C-terminal region and the mature human BMP2 N-terminal region.
Quantity:
200 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001191
Target Species:
Human
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