ABN1488MI
MilliporeSigma™ TIAM-1, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1488MI-Each-of-1 | In Stock | ₹ 38,734.72 |
ABN1488MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
TIAM-1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TIAM1
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody targets a C-terminal region of human and mouse TIAM-1 sequences reported by UniProt (Q13009 and Q60610).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q13009
Immunogen
KLH-conjugated linear peptide corresponding to a C-terminal region sequence of human TIAM-1.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_003244
Target Species
Mouse
Related Products
Description
- T-lymphoma invasion and metastasis-inducing protein 1 (UniProt Q13009; also known as TIAM-1) is encoded by the TIAM1 gene (Gene ID 7074) in human
- TIAM-1 is a ubiquitously expressed guanine nucleotide exchange factor (GEF) that specifically activates the Rho-like GTPase Rac1 in response to growth factors and cell-substrate interaction
- TIAM-1 associates with GTP-bound Ras and functions as an effector that mediates Rac activation by Ras
- TIAM-1 promotes the formation of adherens junctions and the induction of an epithelial-like phenotype in mesenchymal cells, and is essential for the formation and maintenance of cadherin-based adhesions
- Tiam1-knockdown in mice protects against Ras-induced skin carcinogenesis as a result of increased apoptosis and reduced proliferation/growth of keratinocytes
- However, the fewer skin tumors developed progress more frequently to malignancy in Tiam1-knockout mice, indicating that loss of Tiam1 stimulates malignant conversion
- Cellular TIAM-1 is targeted for proteasome-dependent degradation by the SCFbTrCP ubiquitin ligase in cooperation with casein kinase 1 and the MEK/ERK pathway upon mitogenic stimulation.
Compare Similar Items
Show Difference
Antigen: TIAM-1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TIAM1
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody targets a C-terminal region of human and mouse TIAM-1 sequences reported by UniProt (Q13009 and Q60610).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q13009
Immunogen: KLH-conjugated linear peptide corresponding to a C-terminal region sequence of human TIAM-1.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_003244
Target Species: Mouse
Antigen:
TIAM-1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TIAM1
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody targets a C-terminal region of human and mouse TIAM-1 sequences reported by UniProt (Q13009 and Q60610).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q13009
Immunogen:
KLH-conjugated linear peptide corresponding to a C-terminal region sequence of human TIAM-1.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_003244
Target Species:
Mouse
Antigen: Brain lipid binding protein
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Immunohistochemistry, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150mM NaCl) with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged recombinant protein corresponding to human Brain lipid-binding protein.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_001437.1
Target Species: Human, Mouse
Antigen:
Brain lipid binding protein
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Immunohistochemistry, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150mM NaCl) with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant protein corresponding to human Brain lipid-binding protein.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_001437.1
Target Species:
Human, Mouse
Antigen: Prodynorphin/Leumorphin (dynorphin B29)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Pdyn
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antiserum recognizes preproenkephalin-B (a.a. 1-248 of rat sequence), proenkephalin-B (a.a. 22-248 of rat sequence), and leumorphin/dynorphin B-29 (a.a. 221-248 of rat sequence), but not other peptides derived from Proenkephalin-B.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: P06300
Immunogen: Linear peptide corresponding to rat leumorphin (dynorphin B-29) C-terminal half sequence.
Quantity: 50 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_062247
Target Species: Human
Antigen:
Prodynorphin/Leumorphin (dynorphin B29)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Pdyn
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antiserum recognizes preproenkephalin-B (a.a. 1-248 of rat sequence), proenkephalin-B (a.a. 22-248 of rat sequence), and leumorphin/dynorphin B-29 (a.a. 221-248 of rat sequence), but not other peptides derived from Proenkephalin-B.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
P06300
Immunogen:
Linear peptide corresponding to rat leumorphin (dynorphin B-29) C-terminal half sequence.
Quantity:
50 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_062247
Target Species:
Human
Antigen: APP585C
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antibody detects amyloid precursor protein in human Alzheimer's disese brain. It targets an epitope within 9 amino acids in the vicintiy of APP585 in the C-terminal region.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot, Immunohistochemistry (Paraffin)
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: A linear peptide corresponding to 9 amino acids from the C-terminal region of human Amyloid beta A4 protein.
Quantity: 25 μL
Research Discipline: Neuroscience
Gene ID (Entrez): __
Target Species: Mouse, Human
Antigen:
APP585C
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antibody detects amyloid precursor protein in human Alzheimer's disese brain. It targets an epitope within 9 amino acids in the vicintiy of APP585 in the C-terminal region.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
A linear peptide corresponding to 9 amino acids from the C-terminal region of human Amyloid beta A4 protein.
Quantity:
25 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
__
Target Species:
Mouse, Human