ABC1696MI
MilliporeSigma™ APH-1A, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABC1696MI-Each-of-1 | In Stock | ₹ 41,307.51 |
ABC1696MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
APH-1A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
APH1A, PSF, CGI-78, UNQ579/PRO1141
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with all three spliced isoforms of human APH-1A reported by UniProt (Q96BI3).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q96BI3
Immunogen
KLH-conjugated linear peptide corresponding to a sequence from the C-terminal cytoplasmic tail of human APH-1A.
Quantity
100 μg
Research Discipline
Apoptosis & Cancer
Gene ID (Entrez)
NP_001071096
Target Species
Human
Related Products
Description
- Gamma-secretase subunit APH-1A (UniProt Q96BI3; also known as Anterior pharynx defective 1 homolog A, APH-1a, Aph-1alpha, Presenilin-stabilization factor) is encoded by the APH1A (also known as PSF, CGI-78) gene (ORF UNQ579/PRO1141; Gene ID 51107) in human
- Gamma-secretase catalyzes the final cleavage of beta-amyloid precursor protein to generate amyloid-beta peptide, the principal component of amyloid plaques found in Alzheimer's diseased (AD) brains
- Gamma-secretase is a complex composed of four integral membrane proteins, presenilin (PS), nicastrin (NCT), PEN-2, and APH-1
- The PS component could be either a PS1 or PS2 and the APH component could be either an APH-1a or APH-1b, alternative splicings of these four proteins contribute to further heterogeneity among gamma-secretase complexes
- The gamma-secretase complex is assembled in the ER, where NCT and APH-1 form an initial scaffold for the PS holoprotein, which becomes stabilized upon interaction with the NCT/APH-1
- Subsequent addition of PEN-2 to this trimeric assembly intermediate triggers the endoproteolytic cleavage of the PS holoprotein
- The fourth transmembrane domain (TMD4) of APH-1, the PEN-2 C-terminal end, the NCT TMD domain, and the PS1 C-terminal end are shown to be essential for functional gamma-secretase complex assembly
- APH-1a is a seven-transmembrane (a.a
- 3-23, 32-52, 69-89, 119-139, 159-179, 187-207, 214-234) protein with a lumenal N-terminus and a cytoplasmic C-terminal tail (a.a
- 235-265).
Compare Similar Items
Show Difference
Antigen: APH-1A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: APH1A, PSF, CGI-78, UNQ579/PRO1141
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with all three spliced isoforms of human APH-1A reported by UniProt (Q96BI3).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q96BI3
Immunogen: KLH-conjugated linear peptide corresponding to a sequence from the C-terminal cytoplasmic tail of human APH-1A.
Quantity: 100 μg
Research Discipline: Apoptosis & Cancer
Gene ID (Entrez): NP_001071096
Target Species: Human
Antigen:
APH-1A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
APH1A, PSF, CGI-78, UNQ579/PRO1141
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with all three spliced isoforms of human APH-1A reported by UniProt (Q96BI3).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q96BI3
Immunogen:
KLH-conjugated linear peptide corresponding to a sequence from the C-terminal cytoplasmic tail of human APH-1A.
Quantity:
100 μg
Research Discipline:
Apoptosis & Cancer
Gene ID (Entrez):
NP_001071096
Target Species:
Human
Antigen: MLKL
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects Mixed lineage kinase domain-like protein in human cells. It targets an epitope within the first 124 amino acids from the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Western Blot, Immunohistochemistry (Paraffin)
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: GST/His-tagged recombinant fragment corresponding to the first 124 amino acids from the N-terminal region of human Mixed lineage kinase domain-like protein (MLKL).
Quantity: 100 μL
Research Discipline: Apoptosis and Cancer
Gene ID (Entrez): NP_689862
Target Species: Human
Antigen:
MLKL
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects Mixed lineage kinase domain-like protein in human cells. It targets an epitope within the first 124 amino acids from the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
GST/His-tagged recombinant fragment corresponding to the first 124 amino acids from the N-terminal region of human Mixed lineage kinase domain-like protein (MLKL).
Quantity:
100 μL
Research Discipline:
Apoptosis and Cancer
Gene ID (Entrez):
NP_689862
Target Species:
Human
Antigen: Cystatin-C
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to human Cystatin-C.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_000090
Target Species: Human, Mouse, Rat
Antigen:
Cystatin-C
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to human Cystatin-C.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_000090
Target Species:
Human, Mouse, Rat
Antigen: phospho ULK1 (Ser777)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Inhibition Assays, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to a region near the C-terminus of human ULK1 phosphorylated at Ser777.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_033495
Target Species: Human
Antigen:
phospho ULK1 (Ser777)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Inhibition Assays, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to a region near the C-terminus of human ULK1 phosphorylated at Ser777.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_033495
Target Species:
Human