MilliporeSigma™ GADD45 alpha, Rabbit, Unlabeled, Polyclonal,

Description

• Growth arrest and DNA damage-inducible protein GADD45 alpha (UniProt P24522; also known as DDIT-1, DNA damage-inducible transcript 1 protein) is encoded by the GADD45A (also known as DDIT1, GADD45) gene (Gene ID 1647) in human
• GADD45A, GADD45B, and GADD45G constitute a family of sensors that can mediate rapid responses to a variety of stressors in mammals
• GADD45 proteins are involved in cellular DNA repair, cell cycle, cell survival, apoptosis, senescence, and DNA demethylation under various stress conditions
• The interaction of GADD45 with PCNA regulates DNA replication and repair by stimulating nucleotide excision repair
• GADD45 can induce cell cycle arrest through direct interaction with cell cycle-related protein CDK1 and p21
• Direct phosphorylation of MEKK4 by GADD45 leads to activation of JNK and p38 kinase, resulting in cellular apoptosis and senescence, respectively
• All GADD45 proteins are able to interact with each other and form homo- or hetero-dimers, which are crucial for GADD45 functions
• GADD45 proteins are ubiquitously expressed, but can vary in their tissue expression patterns among the three members
• Gadd45a deletion in mice causes genomic instability, resulting in defective mitosis and cytokinesis, as wll as increased radiation carcinogenesis
• In addition to the reported antitumor activity via the induction of cellular apoptosis or senescence in cancer cells, GADD45A has also been shown to play a role in facilitating tumorigenesis in certain cancers.