ERK1 Mouse, Unlabeled, Clone: G262-118, BD

Description

• A serine/threonine specific protein kinase, called MAP kinase or more recently ERK1 (extracellular signal regulated kinase) is activated in cells following stimulation with EGF (epidermal growth factor), the PDGF (platelet-derived factor) or insulin
• ERK1 has been assayed in vitro for phosphotransferase activity using the microtubule-associated protein (MAP) or myelin basic protein
• The mechanism by which MAP kinase becomes activated in growth factor treated cells is thought to involve tyrosine and threonine phosphorylation of the kinase itself
• The EGF, PDGF and insulin receptors are known to be tyrosine specific protein kinases and studies have shown that MAP kinase is identical to the p42 protein that earlier studies identified as one of the major tyrosine phosphorylated proteins in transformed or growth factor treated cells
• While several isoforms of the p42 protein are known, they are thought to be structurally similar
• The G262-118 antibody recognizes human and mouse ERK1
• It does not cross-react with ERK2
• A synthetic peptide from the C-terminal region of ERK1 was used as immunogen
• Host Species: Mouse Clone: G262-118 Isotype: IgG2b Species Reactivity: Mouse Immunogen: C-Terminal Region of ERK1 Formula Weight [Chemical]: 44kDa Western Blotting