Stat4 Mouse, Unlabeled, Clone: 8, BD

Description

• The Stat proteins function as both cytoplasmic signal transducers and activators of transcription
• Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family
• With the discovery of additional members of the Stat family (Stat 3 & 4), the nomenclature has been revised to reflect the order of their discovery
• Stat 91, 84, and 113 have become Stat1α, Stat1β, and Stat2, respectively
• Stat4 has been reported to be 52% identical to Stat1 and 47% identical to Stat3
• Functionally, Stat4 is similar to the other Stat proteins in that it requires tyrosine phosphorylation in order to stimulate its IFN-γ activated site (GAS) binding activity
• Expression of Stat4 appears to be limited to thymus, spleen, and testis
• Its expression in several myeloid cell lines is differentially regulated during cellular differentiation
• Co-transfection studies using JAK1 or JAK2 expression constructs indicate that Stat4 is a substrate for these kinases
• Immunofluorescence, Western Blotting