PI3-Kinase p110α Mouse, Unlabeled, Clone: 19, BD

Description

• Phosphatidylinositol 3 (PI3) -kinase participates in insulin-stimulated glucose uptake, PDGF-induced membrane ruffling, and G-protein receptor signaling
• It exists as a heterodimer of 85kDa (p85) and 110kDa (p110) subunits
• The p85 subunit associates with and serves as a substrate for activated growth factor receptor tyrosine kinases
• p85 regulates the p110 catalytic subunit by acting as the link between PI3-kinase and the ligand-activated receptor
• Four isoforms of p110 have been identified (α, β, γ, and δ)
• The p110α isoform contains an N-terminal region involved in p85 binding and a C-terminal kinase domain
• p85/p110α-type PI kinase phosphorylates the D-3 and D-4 position of the inositol ring of PI, thereby producing PtdIns(3)P, PtdIns(3,4)P[2], PtdIns(3,4,5)P[3], PtdIns(4)P, and PtdIns(4,5) P[2]
• During induction of chemotaxis by the chemokine SDF-1α, PI3-kinase regulates adhesion and ERM protein redistribution in the lymphocyte plasma membrane
• In addition, PI3-kinases activate other signaling molecules, such as p70 S6 kinase and Akt/protein kinase B
• Thus, p85/p110α-type PI kinase is a ubiquitously expressed kinase that is involved in a variety of cell signaling cascades
• Host Species: Mouse Clone: 19 Isotype: IgG1 Species Reactivity: Human Immunogen: Human PI3-Kinase p110α aa
• 101-300 Formula Weight [Chemical]: 110kDa Immunofluorescence, Western Blotting