MSR1 (CD204) Mouse, anti-Human, R718, Clone: U23-56, BD OptiBuild™

Description

• The U23-56 monoclonal antibody specifically binds to Macrophage scavenger receptor 1 (MSR1) which is also known as CD204, Scavenger receptor A (SRA), Scavenger receptor class A member 1 (SCARA1), or Macrophage acetylated LDL receptor I and II
• MSR1 is a trimeric type II transmembrane glycoprotein that belongs to the type 1 class A scavenger receptor family
• MSR1 functions as a scavenger receptor that enables mononuclear phagocytes to take up and respond to a variety of negatively charged macromolecules including oxidized and acetylated low density lipoproteins
• MSR1 also functions in innate immunity as a pattern recognition receptor
• MSR1 allows macrophages to recognize and respond to microbial products, such as lipopolysaccharide and polyribonucleic acids, by the production of cytokines and inflammatory mediators
• MSR1 also reportedly serves as a coreceptor that regulates the signaling of some Toll-like receptors including TLR-3, TLR-4, and TLR-9
• MSR1 has been associated with several diseases including atherosclerosis, Alzheimer's disease, ischemic injury, and sepsis
• The U23-56 antibody was tested by flow cytometric and Western blot analyses of MSR1-transfected and untransfected cells to verify its specificity.