MilliporeSigma™ Integrin β1, activated, Mouse, Alexa Fluor 555, Clone: HUTS-4,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MAB2079AF55-Each-of-1 | In Stock | ₹ 44,990.87 |
MAB2079AF55 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,990.87
GST (18%): ₹ 8,098.357
Total Price: ₹ 53,089.227
Antigen
Integrin β1, activated
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2a antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % Sodium Azide.
Gene Accession No.
P05556
Immunogen
Generated against human β1 integrins purified from Triton X-100 lysates of human lung, liver, and skeletal muscle tissues.
Quantity
100 μL
Research Discipline
Cell Structure
Gene ID (Entrez)
NM_002292.3
Target Species
Human
Form
Purified
Applications
Immunocytochemistry
Clone
HUTS-4
Conjugate
Alexa Fluor 555
Gene
ITGB1, FNRB, MDF2, MSK12, VLA-BETA, VLAB
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone HUTS-4 is specific for active conformation of human beta1 integrins. The beta1 or VLA integrin subgroup contains at least 10 members, each with a distinct alpha subunit nonconvalently associated with the common beta1 subunit. Functional activation of integrins can be experimentally induced by addition of Mg2+ or Mn2+, or by using one of several stimulatory antibodies that are available. Intracellular signals generated as a result of cell activation also modulate the confirmation and affinity of integrins in cellular systems. Antibodies such as clone HUTS-4 which have the ability to discriminate between different states of integrin activation are exceptionally useful for studies on the regulation of activation. Clone HUTS-4 recognizes epitopes in the 355-425 region of the common beta1 subunit of VLA integrins, whose expression parallels the ligand binding activity of these adhesion receptors induced by various extracellular and intracellular stimuli.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a
Related Products
Description
- Integrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human
- Integrin beta-1 is a 130kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins
- Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death
- They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis
- These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells
- Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.
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Antigen: Integrin β1, activated
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG2a antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % Sodium Azide.
Gene Accession No.: P05556
Immunogen: Generated against human β1 integrins purified from Triton X-100 lysates of human lung, liver, and skeletal muscle tissues.
Quantity: 100 μL
Research Discipline: Cell Structure
Gene ID (Entrez): NM_002292.3
Target Species: Human
Form: Purified
Applications: Immunocytochemistry
Clone: HUTS-4
Conjugate: Alexa Fluor 555
Gene: ITGB1, FNRB, MDF2, MSK12, VLA-BETA, VLAB
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone HUTS-4 is specific for active conformation of human beta1 integrins. The beta1 or VLA integrin subgroup contains at least 10 members, each with a distinct alpha subunit nonconvalently associated with the common beta1 subunit. Functional activation of integrins can be experimentally induced by addition of Mg2+ or Mn2+, or by using one of several stimulatory antibodies that are available. Intracellular signals generated as a result of cell activation also modulate the confirmation and affinity of integrins in cellular systems. Antibodies such as clone HUTS-4 which have the ability to discriminate between different states of integrin activation are exceptionally useful for studies on the regulation of activation. Clone HUTS-4 recognizes epitopes in the 355-425 region of the common beta1 subunit of VLA integrins, whose expression parallels the ligand binding activity of these adhesion receptors induced by various extracellular and intracellular stimuli.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a
Antigen: MEK1
Classification: Monoclonal
Concentration: LYOPH
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene Accession No.: Q02750
Immunogen: E. coli-derived recombinant human MEK1 Lys2-Val393 (Ser218Asp, Ser222Asp) Accession # Q02750
Quantity: 25 μg
Research Discipline: __
Gene ID (Entrez): 5604
Target Species: Human, Mouse, Rat
Form: Purified
Applications: Western Blot
Clone: 239421
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein A or G purified from hybridoma culture supernatant
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Detects human, mouse, and rat MEK1 in Western blots. In Western blots, no crossreactivity with recombinant human MEK2 is observed.
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Isotype: IgG2a
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
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