MABN821MI
MilliporeSigma™ polyQ Disease Proteins, Mouse, Unlabeled, Clone: 3B5H10,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN821MI-Each-of-1 | In Stock | ₹ 39,152.26 |
MABN821MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,152.26
GST (18%): ₹ 7,047.407
Total Price: ₹ 46,199.667
Antigen
polyQ Disease Proteins
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P42858
Immunogen
N-terminally GST-tagged human Huntingtin (Htt) fragment corresponding to exon 1-coded seqeunce containing a stretch of 66 glutamines (GST-171-Q66; Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Quantity
100 μg
Research Discipline
Neuroscience
Test Specificity
Clone 3B5H10 targeted epitope is exposed among some of the many conformations adopted by monomeric and possibly small oligomeric polyQ species of mutant Huntingtin protein (mHtt), but disappears in higher-molecular weight aggregated forms, such as inclusion bodies (IBs). The epitope also exists in mutant forms of other polyQ-containing proteins that cause neurodegeneration, including the androgen receptor, atrophin, and ataxin-3 (Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry, Inhibition Assays, Western Blot
Clone
3B5H10
Conjugate
Unconjugated
Gene
HTT, HD, IT15
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Huntingtin (UniProt P42858; also known as HD protein, Huntington disease protein) is encoded by the HTT (also known as HD, IT15) gene (Gene ID 3064) in human
- Misfolding and self-aggregation of specific proteins are a common feature of well known neurodegenerative diseases, including Huntington s disease (HD), Alzheimer's disease (AD), Parkinson s disease (PD), and amyotrophic lateral sclerosis (AML)
- Abnormal polyglutamine (polyQ) repeat sequence or stretch result in protein misfolding and neurodegeneration
- HD, for example, is caused by polyQ expansion in the first exon-coded sequence of the causal protein Huntingtin (Htt exon 1)
- The expanded polyQ leads to formation of beta-sheet rich fibrillar aggregates called amyloid
- Eight proteins containing polyQ tracts, but otherwise unrelated to htt, also result in protein misfolding and neurodegeneration upon polyQ expansion
- Growing evidences implicate soluble oligomers or even monomers of disease-causing amyloid proteins as the more toxic species
- In HD, formation of the end-stage, very large aggregated species of mutant htt (mHtt), termed an inclusion bodies (IBs), is believed to be a coping response to sequester toxic species of monomeric or small oligomeric mHtt, which are distributed diffusely throughout the neuron.
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Antigen: polyQ Disease Proteins
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P42858
Immunogen: N-terminally GST-tagged human Huntingtin (Htt) fragment corresponding to exon 1-coded seqeunce containing a stretch of 66 glutamines (GST-171-Q66; Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: Clone 3B5H10 targeted epitope is exposed among some of the many conformations adopted by monomeric and possibly small oligomeric polyQ species of mutant Huntingtin protein (mHtt), but disappears in higher-molecular weight aggregated forms, such as inclusion bodies (IBs). The epitope also exists in mutant forms of other polyQ-containing proteins that cause neurodegeneration, including the androgen receptor, atrophin, and ataxin-3 (Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry, Inhibition Assays, Western Blot
Clone: 3B5H10
Conjugate: Unconjugated
Gene: HTT, HD, IT15
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
polyQ Disease Proteins
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P42858
Immunogen:
N-terminally GST-tagged human Huntingtin (Htt) fragment corresponding to exon 1-coded seqeunce containing a stretch of 66 glutamines (GST-171-Q66; Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
Clone 3B5H10 targeted epitope is exposed among some of the many conformations adopted by monomeric and possibly small oligomeric polyQ species of mutant Huntingtin protein (mHtt), but disappears in higher-molecular weight aggregated forms, such as inclusion bodies (IBs). The epitope also exists in mutant forms of other polyQ-containing proteins that cause neurodegeneration, including the androgen receptor, atrophin, and ataxin-3 (Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunohistochemistry, Inhibition Assays, Western Blot
Clone:
3B5H10
Conjugate:
Unconjugated
Gene:
HTT, HD, IT15
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: LRRTM4
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q86VH4
Immunogen: Conjugated linear peptide corresponding to human LRRTM4.
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: N205B/22
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
LRRTM4
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q86VH4
Immunogen:
Conjugated linear peptide corresponding to human LRRTM4.
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
N205B/22
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: Retinal Dehydrogenase 1/ALDH1A1
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1k antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P00352
Immunogen: GST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: __
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 8D7.1
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Retinal Dehydrogenase 1/ALDH1A1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1k antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P00352
Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
__
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
8D7.1
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: Semaphorin 4A
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgMκ antibody in PBS with 0.05% sodium azide.
Gene Accession No.: Q9H3S1
Immunogen: GST-tagged recombinant protein corresponding to the Sema domain of human Semaphorin 4A.
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgM κ
Applications: Western Blot
Clone: 8B5.1
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Purified by Ion-Exchange Chromatography
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Semaphorin 4A
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgMκ antibody in PBS with 0.05% sodium azide.
Gene Accession No.:
Q9H3S1
Immunogen:
GST-tagged recombinant protein corresponding to the Sema domain of human Semaphorin 4A.
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgM κ
Applications:
Western Blot
Clone:
8B5.1
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Purified by Ion-Exchange Chromatography
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified