MABN784MI
MilliporeSigma™ anti-FMR1polyG Clone: 2J7,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN784MI-Each-of-1 | In Stock | ₹ 36,363.00 |
MABN784MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,363.00
GST (18%): ₹ 6,545.34
Total Price: ₹ 42,908.34
Antigen
FMR1polyG
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q06787
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
2J7
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
FMR1, FRAXA, POF1
Immunogen
Ovalbumin-conjugated linear peptide corresponding to a sequence from the C-terminal region of FMR1polyG.
Quantity
100 μg
Research Discipline
Neuroscience
Test Specificity
This Monoclonal does not detect the Fragile X mental retardation protein 1 sequences reported by UniProt (Q06787-1 through Q06787-9). It detects one of the two possible types of FMR1 frame-shift sequences with N-terminal polyG fusion found in Fragile X-associated Tremor/Ataxia syndrome (FXTAS) patients due to CGG repeats expansion (55 to 200 repeats) in the 5’UTR of the FMR1 gene. Due to the extended aggregation of the pathological forms of FMR1polyG, the detection of FMR1polyG in patient samples by Western blotting is not recommended.
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG2b κ
Related Products
Description
- Specifically detects FMR1polyG Clone: 2J7 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Western Blotting Fragile X-associated Tremor/Ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by an elevated CGG-repeat expansions (55-200) in the 5' UTR of the fragile-X mental retardation 1 gene FMR1 (also known as FRAXA, POF1; Gene ID 2332) on the X-chromosome
- The CGG repeat expansion in FXTAS triggers repeat-associated non-ATG-initiated translation (RAN or RANT), also known as repeat-associated non-AUG-initiated translation, within the 5’UTR of FMR1 mRNA, resulting in the production of fusion proteins (FMR1polyG) that contain N-terminal polyglycine fused to either C-terminal FMR1 in-frame sequence or one of two FMR1 frame-shift sequences
- Immunohistochemical analysis of FXTAS brain tissues reveals FMR1polyG-positive aggregates that closely resemble neuronal intranuclear inclusions seen in polyglutamine diseases and other protein-mediated neurodegenerative disorders
- Much larger expansions of the same repeat cause fragile X syndrome (FRAX), the most common inherited form of mental retardation, by silencing FMR1 transcription.
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Antigen: FMR1polyG
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: Q06787
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 2J7
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: FMR1, FRAXA, POF1
Immunogen: Ovalbumin-conjugated linear peptide corresponding to a sequence from the C-terminal region of FMR1polyG.
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: This Monoclonal does not detect the Fragile X mental retardation protein 1 sequences reported by UniProt (Q06787-1 through Q06787-9). It detects one of the two possible types of FMR1 frame-shift sequences with N-terminal polyG fusion found in Fragile X-associated Tremor/Ataxia syndrome (FXTAS) patients due to CGG repeats expansion (55 to 200 repeats) in the 5’UTR of the FMR1 gene. Due to the extended aggregation of the pathological forms of FMR1polyG, the detection of FMR1polyG in patient samples by Western blotting is not recommended.
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2b κ
Antigen:
FMR1polyG
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
Q06787
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
2J7
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
FMR1, FRAXA, POF1
Immunogen:
Ovalbumin-conjugated linear peptide corresponding to a sequence from the C-terminal region of FMR1polyG.
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
This Monoclonal does not detect the Fragile X mental retardation protein 1 sequences reported by UniProt (Q06787-1 through Q06787-9). It detects one of the two possible types of FMR1 frame-shift sequences with N-terminal polyG fusion found in Fragile X-associated Tremor/Ataxia syndrome (FXTAS) patients due to CGG repeats expansion (55 to 200 repeats) in the 5’UTR of the FMR1 gene. Due to the extended aggregation of the pathological forms of FMR1polyG, the detection of FMR1polyG in patient samples by Western blotting is not recommended.
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2b κ
Antigen: Dual oxidase 2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: NP_054799
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: Duox S-12
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: DUOX2, LNOX2, THOX2
Immunogen: Recombinant protein corresponding to the N-terminus of human Dual oxidase 2.
Quantity: 100 μg
Research Discipline: __
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG1 κ
Antigen:
Dual oxidase 2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
NP_054799
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
Duox S-12
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
DUOX2, LNOX2, THOX2
Immunogen:
Recombinant protein corresponding to the N-terminus of human Dual oxidase 2.
Quantity:
100 μg
Research Discipline:
__
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG1 κ
Antigen: __
Classification: __
Conjugate: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Applications: __
Clone: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Antigen: nitrated Hsp90
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat
Form: Purified
Applications: Dot Blot, ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone: 44.23
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Hsp90ab1;Hsp84;Hspcb
Immunogen: Purified, nitrated HSP90 from rat liver.
Quantity: 25 μg
Research Discipline: Neuroscience
Test Specificity: Clone 44.23 detects nitrated HSP90 in rat, but not HSP90. It specifically targets nitrotyrosine 56.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Antigen:
nitrated Hsp90
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat
Form:
Purified
Applications:
Dot Blot, ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone:
44.23
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Hsp90ab1;Hsp84;Hspcb
Immunogen:
Purified, nitrated HSP90 from rat liver.
Quantity:
25 μg
Research Discipline:
Neuroscience
Test Specificity:
Clone 44.23 detects nitrated HSP90 in rat, but not HSP90. It specifically targets nitrotyrosine 56.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1