MilliporeSigma™ TIM-1, Rat, Unlabeled, Clone: 3B3,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF245-Each-of-1 | In Stock | ₹ 41,308.37 |
MABF245 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,308.37
GST (18%): ₹ 7,435.507
Total Price: ₹ 48,743.877
Antigen
TIM-1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat IgG2a in buffer containing PBS without preservatives.
Gene Accession No.
Q5QNS5
Immunogen
Recombinant TIM-1 Ig fusion consists of mouse TIM-1 signal and IgV domains linked to the hinge-CH2-CH3 domains of mouse IgG2a (Umetsu, S.E., et al. (2005). Nat. Immunol.6(5):447-454).
Quantity
100 μg
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_001160103
Target Species
Mouse
Form
Purified
Applications
Functional Assay
Clone
3B3
Conjugate
Unconjugated
Gene
Havcr1, Kim1, Tim1, Timd1
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3B3 detected recombinant murine TIM-1, but not TIM-3 or TIM-4, Ig fusion. Clone 3B3 immunostained the surface of TIM-1-transfected, but not untransfected 300.19 mouse pre-B-cells (Umetsu, S.E., et al. (2005). Nat. Immunol.6(5):447-454). Clone 3B3 and clone RMT1-10 (Mfr. No. MABF225) exhibited opposite effects toward T cell antigen responses (Xiao, S., et al. (2007). J. Exp. Med. 204(7):1691-1702).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG2a κ
Related Products
Description
- Hepatitis A virus cellular receptor 1 homolog (UniProt Q5QNS5; also known as HAVcr-1, Kidney injury molecule 1, KIM-1, T cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin mucin receptor 1, T cell membrane protein 1, TIM-1, TIMD-1) is encoded by the Havcr1 (also known as Kim1, Tim1, Timd1) gene (Gene ID 171283) in murine species
- TIM‐1/KIM‐1 is a phosphatidylserine phagocytosis and scavenger receptor expressed on kidney proximal tubule epithelial cells and, at a much lower level, also among a subset of immune cells
- Upon kidney injury, TIM‐1 is upregulated more than a thousand fold and assists tissue injury recovery through phagocytosis of apoptotic cells and cellular debris
- KIM‐1‐mediated phagocytosis leads to pro‐tolerogenic antigen presentation, which suppresses CD4+ T‐cell proliferation and increases the percentage of regulatory T-cells in an autophagy gene‐dependent manner
- Phagocytosis mediated by KIM‐1 in epithelial cells therefore limits inflammation by both removing dead cells and inducing anti‐inflammatory Treg signaling
- Human HAVCR1 polymorphisms are linked to various immunological disorders including allergy, asthma, rheumatoid arthritis, atopic dermatitis, and lupus
- TIM-1 is produced with a signal peptide (a.a
- 1-21) sequence which is removed posttranslationally to yield the mature protein with a large extracellular region (a.a
- 21-290 in human and 22-237 in mouse) composed of a V-type Ig-like domain (a.a
- 21-121 in human and 22-122 in mouse) and a mucin domain (the rest of the extracellular region), followed by a transmembrane domain (a.a
- 238-258), and a cytoplasmic tail (a.a
- 312-359 in human and 259-305 in mouse) with tyrosine phosphorylation sites.
Compare Similar Items
Show Difference
Antigen: TIM-1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat IgG2a in buffer containing PBS without preservatives.
Gene Accession No.: Q5QNS5
Immunogen: Recombinant TIM-1 Ig fusion consists of mouse TIM-1 signal and IgV domains linked to the hinge-CH2-CH3 domains of mouse IgG2a (Umetsu, S.E., et al. (2005). Nat. Immunol.6(5):447-454).
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_001160103
Target Species: Mouse
Form: Purified
Applications: Functional Assay
Clone: 3B3
Conjugate: Unconjugated
Gene: Havcr1, Kim1, Tim1, Timd1
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3B3 detected recombinant murine TIM-1, but not TIM-3 or TIM-4, Ig fusion. Clone 3B3 immunostained the surface of TIM-1-transfected, but not untransfected 300.19 mouse pre-B-cells (Umetsu, S.E., et al. (2005). Nat. Immunol.6(5):447-454). Clone 3B3 and clone RMT1-10 (Mfr. No. MABF225) exhibited opposite effects toward T cell antigen responses (Xiao, S., et al. (2007). J. Exp. Med. 204(7):1691-1702).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG2a κ
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen: Tapasin
Classification: Monoclonal
Concentration: __
Formulation: Purified rat monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: np_003181
Immunogen: Linear peptide corresponding to human Tapasin.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Rat
Form: Purified
Applications: Flow Cytometry, Western Blot
Clone: 7F6
Conjugate: Unconjugated
Gene: __
Host Species: Rat
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG1 κ
