MABF919MI
MilliporeSigma™ Ly108/Slamf6, Rat, Unlabeled, Clone: 3E11,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF919MI-Each-of-1 | In Stock | ₹ 41,307.51 |
MABF919MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
Ly108/Slamf6
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat monoclonal IgG2a in buffer containing PBS without preservatives.
Gene Accession No.
Q9ET39
Immunogen
Murine Ly108-human IgG1 Fc fusion protein.
Quantity
100 μg
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_109635.1
Target Species
Mouse
Form
Purified
Applications
Functional Assay, Immunoprecipitation, Western Blot
Clone
3E11
Conjugate
Unconjugated
Gene
Slamf6, Ly108
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3E11 specifically detected exogenously expressed murine Ly108-1 (Ly108s; UniProt Q9ET39-2) and Ly108-2 (Ly108l; UniProt Q9ET39-1), but not other SLAM family members (2B4, CD84, CRACC, Ly-9, and SLAM) on the surface of respective mouse BI-141 T cell transfectants. Murine Ly108 spliced isoforms Ly108-1 (Ly108s; UniProt Q9ET39-2), Ly108-2 (Ly108l; UniProt Q9ET39-1) and Ly108-3 (Not reported by UniProt) differ in their cytoplasmic C-terminal end sequence, but are identical in the rest of their sequence, including the extracellular region targeted by clone 3E11 (Zhong, M.C., and Veillette, A. (2008). J. Biol. Chem. 283(28):19255 -19264).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG2a κ
Related Products
Description
- SLAM family member 6 (UniProt Q9ET39; also known as CD352, NK-T-B-antigen, NTB-A, Lymphocyte antigen 108) is encoded by the Slamf6 (also known as Ly108) gene (Gene ID 30925) in murine species
- Ly108/Slamf6 belongs to the 7-member (SLAM/CD150, CD48/SLAMF2, Ly-9/CD229, 2B4/CD244, CD84/SLAMF5, Ly108/NTB-A/CD352, CRACC) signaling lymphocytic activation molecule family (SLAMF) of receptors broadly expressed in hematopoietic cells
- 2B4 and CD48 interact with eath other, while rest of the family members act as self-ligands, where two identical molecules on the surface of two different cells can interact as receptor and ligand to each other
- SLAMF members carry one or more copies of immunoreceptor tyrosine-based switch motif or ITSM (TxYxxV/I) in their cytoplasmic tails
- Upon phosphorylation on the tyrosine residue, ITSM mediates the recruitment of SH2 domain-containing signaling molecules such as SLAM-associated protein (SAP), including SAP in T-, NK, and NK T-cells, EAT-2A and EAT-2B (murine) in NK cells and APCs
- Ly108/Slamf6 is synthesized with a signal peptide sequence (mouse a.a
- 1-30), the removal of which yields the mature Ly108 with an extracellular region (a.a
- 31-239) that contains a V-type and a C2-type Ig-like domain (a.a
- 36-130 and 147-210), followed by a single transmembrane domain (a.a
- 240-262) and a cytoplasmic tail (a.a
- 263-351)
- Ly108/Slamf6 cytoplasmic domain contains two copies of ITSM (mouse a.a
- 293-TVYAQV-298 and 317-TIYSIV-322)
- Alternative splicings produce three Ly108 isoforms, Ly108-1 (Ly108s; UniProt Q9ET39-2), Ly108-2 (Ly108l; UniProt Q9ET39-1) and Ly108-3 (Not reported by UniProt), that differ in their cytoplasmic C-terminal end sequence, but are identical in the rest of their sequence.
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Antigen: Ly108/Slamf6
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat monoclonal IgG2a in buffer containing PBS without preservatives.
Gene Accession No.: Q9ET39
Immunogen: Murine Ly108-human IgG1 Fc fusion protein.
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_109635.1
Target Species: Mouse
Form: Purified
Applications: Functional Assay, Immunoprecipitation, Western Blot
Clone: 3E11
Conjugate: Unconjugated
Gene: Slamf6, Ly108
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3E11 specifically detected exogenously expressed murine Ly108-1 (Ly108s; UniProt Q9ET39-2) and Ly108-2 (Ly108l; UniProt Q9ET39-1), but not other SLAM family members (2B4, CD84, CRACC, Ly-9, and SLAM) on the surface of respective mouse BI-141 T cell transfectants. Murine Ly108 spliced isoforms Ly108-1 (Ly108s; UniProt Q9ET39-2), Ly108-2 (Ly108l; UniProt Q9ET39-1) and Ly108-3 (Not reported by UniProt) differ in their cytoplasmic C-terminal end sequence, but are identical in the rest of their sequence, including the extracellular region targeted by clone 3E11 (Zhong, M.C., and Veillette, A. (2008). J. Biol. Chem. 283(28):19255 -19264).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG2a κ
Antigen:
Ly108/Slamf6
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rat monoclonal IgG2a in buffer containing PBS without preservatives.
Gene Accession No.:
Q9ET39
Immunogen:
Murine Ly108-human IgG1 Fc fusion protein.
Quantity:
100 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_109635.1
Target Species:
Mouse
Form:
Purified
Applications:
Functional Assay, Immunoprecipitation, Western Blot
Clone:
3E11
Conjugate:
Unconjugated
Gene:
Slamf6, Ly108
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 3E11 specifically detected exogenously expressed murine Ly108-1 (Ly108s; UniProt Q9ET39-2) and Ly108-2 (Ly108l; UniProt Q9ET39-1), but not other SLAM family members (2B4, CD84, CRACC, Ly-9, and SLAM) on the surface of respective mouse BI-141 T cell transfectants. Murine Ly108 spliced isoforms Ly108-1 (Ly108s; UniProt Q9ET39-2), Ly108-2 (Ly108l; UniProt Q9ET39-1) and Ly108-3 (Not reported by UniProt) differ in their cytoplasmic C-terminal end sequence, but are identical in the rest of their sequence, including the extracellular region targeted by clone 3E11 (Zhong, M.C., and Veillette, A. (2008). J. Biol. Chem. 283(28):19255 -19264).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG2a κ
Antigen: SAP/SH2D1A
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: O88890
Immunogen: GST-tagged recombinant full-length mouse SAP.
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_035494
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 1A9
Conjugate: Unconjugated
Gene: Sh2d1a, Xlp
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1A9 reacts with SAP, but not EAT-2 or ERT (Roncagalli, R., et al. (2005). Nat. Immunol. 6(10):1002-1010). Clone 1A9 immunostained wild-type, but not sh2d1a-knockout murine peripheral blood CD3+CD4+ lymphocytes (Zhong, M.C., and Veillette, A. (2013). Mol. Cell. Biol. 33(6):1223-1232).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
SAP/SH2D1A
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
O88890
Immunogen:
GST-tagged recombinant full-length mouse SAP.
Quantity:
100 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_035494
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
1A9
Conjugate:
Unconjugated
Gene:
Sh2d1a, Xlp
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1A9 reacts with SAP, but not EAT-2 or ERT (Roncagalli, R., et al. (2005). Nat. Immunol. 6(10):1002-1010). Clone 1A9 immunostained wild-type, but not sh2d1a-knockout murine peripheral blood CD3+CD4+ lymphocytes (Zhong, M.C., and Veillette, A. (2013). Mol. Cell. Biol. 33(6):1223-1232).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: CD99
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG3κ antibody in PBS without preservatives.
Gene Accession No.: P14209
Immunogen: Human thymocytes.
Quantity: 100 μg
Research Discipline: Inflammation, Immunology
Gene ID (Entrez): NP_001116370
Target Species: Human
Form: Purified
Applications: Functional Assay, Flow Cytometry, Western Blot
Clone: O662
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 0662 detects both the 32kDa glycosylated (plasma membrane) and the 28kDa non-glycosylated (intracellular) forms of human CD99/E2 (Gelin, C., et al. (1989). EMBO J. 8(11):3253-3259). Note that the clone was originally designated as 0662 (zero six six two) by Bernard, A., et al. (1988), but subsequently cited in some publications as O662 with a captial letter O.
Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype: IgG3 κ
Antigen:
CD99
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG3κ antibody in PBS without preservatives.
Gene Accession No.:
P14209
Immunogen:
Human thymocytes.
Quantity:
100 μg
Research Discipline:
Inflammation, Immunology
Gene ID (Entrez):
NP_001116370
Target Species:
Human
Form:
Purified
Applications:
Functional Assay, Flow Cytometry, Western Blot
Clone:
O662
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 0662 detects both the 32kDa glycosylated (plasma membrane) and the 28kDa non-glycosylated (intracellular) forms of human CD99/E2 (Gelin, C., et al. (1989). EMBO J. 8(11):3253-3259). Note that the clone was originally designated as 0662 (zero six six two) by Bernard, A., et al. (1988), but subsequently cited in some publications as O662 with a captial letter O.
Content And Storage:
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype:
IgG3 κ
Antigen: CD84/Slamf5
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q18PI6
Immunogen: Human IgG1 Fc-tagged recombinant mouse CD84 extracellular domain.
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_038517.1
Target Species: Mouse
Form: Purified
Applications: Flow Cytometry
Clone: 1D3
Conjugate: Unconjugated
Gene: Cd84, Slamf5
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1D3 immunostained the surface of murine CD84-transfected, but not untranfected, BI-141 murine T-cells (Cruz-Munoz, M.E., et al. (2009). Nat. Immunol. 10(3):297-305). Reactivity toward spliced isoform 2 has not been determined.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
CD84/Slamf5
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rat IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q18PI6
Immunogen:
Human IgG1 Fc-tagged recombinant mouse CD84 extracellular domain.
Quantity:
100 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_038517.1
Target Species:
Mouse
Form:
Purified
Applications:
Flow Cytometry
Clone:
1D3
Conjugate:
Unconjugated
Gene:
Cd84, Slamf5
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1D3 immunostained the surface of murine CD84-transfected, but not untranfected, BI-141 murine T-cells (Cruz-Munoz, M.E., et al. (2009). Nat. Immunol. 10(3):297-305). Reactivity toward spliced isoform 2 has not been determined.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ