MABF920MI
MilliporeSigma™ SAP/SH2D1A, Rat, Unlabeled, Clone: 1A9,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF920MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABF920MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
SAP/SH2D1A
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O88890
Immunogen
GST-tagged recombinant full-length mouse SAP.
Quantity
100 μg
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_035494
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1A9
Conjugate
Unconjugated
Gene
Sh2d1a, Xlp
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1A9 reacts with SAP, but not EAT-2 or ERT (Roncagalli, R., et al. (2005). Nat. Immunol. 6(10):1002-1010). Clone 1A9 immunostained wild-type, but not sh2d1a-knockout murine peripheral blood CD3+CD4+ lymphocytes (Zhong, M.C., and Veillette, A. (2013). Mol. Cell. Biol. 33(6):1223-1232).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- SH2 domain-containing protein 1A (UniProt O60880; also known as Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP) is encoded by the Sh2d1a (also known as Xlp) gene (Gene ID 20400) in murine species
- SAP/SH2D1A is a 628-amino acid (isoform A) adaptor protein expressed in T cells, natural killer (NK) cells, NK-T cells, and some B cells
- SAP/SH2D1A is made up almost exclusively of a Src homology 2 (SH2) domain (a.a
- 6-104) and plays an important role in multiple immune cell functions, including T helper 2 (TH2) cytokine production, T cell-dependent antibody production, follicular T helper (TFH) cell differentiation, NK-T cell development, CD8+ T cell- and NK cell-mediated cytotoxicity
- SAP couples signaling lymphocytic activation molecule (SLAM) family receptors to tyrosine phosphorylation signals through its interaction with the SH3 domain of Src family protein tyrosine kinase Fyn
- In addition, SAP can prevent SH2 domain-containing negative regulators, such as phosphatases SHIP-1 and SHP-1, from inactivating SLAM-related receptors by blocking their interaction with the receptors
- Evidence also shows that SAP/SH2D1A regulates T cell-dependent antibody production and TFH cell differentiation independent of Fyn
- SAP/SH2D1A gene is mutated and inactivated in X-linked lymphoproliferative disease, a rare human immunodeficiency characterized by an uncontrolled immune response to Epstein-Barr virus infection.
Compare Similar Items
Show Difference
Antigen: SAP/SH2D1A
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: O88890
Immunogen: GST-tagged recombinant full-length mouse SAP.
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_035494
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 1A9
Conjugate: Unconjugated
Gene: Sh2d1a, Xlp
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1A9 reacts with SAP, but not EAT-2 or ERT (Roncagalli, R., et al. (2005). Nat. Immunol. 6(10):1002-1010). Clone 1A9 immunostained wild-type, but not sh2d1a-knockout murine peripheral blood CD3+CD4+ lymphocytes (Zhong, M.C., and Veillette, A. (2013). Mol. Cell. Biol. 33(6):1223-1232).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
SAP/SH2D1A
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
O88890
Immunogen:
GST-tagged recombinant full-length mouse SAP.
Quantity:
100 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_035494
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
1A9
Conjugate:
Unconjugated
Gene:
Sh2d1a, Xlp
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1A9 reacts with SAP, but not EAT-2 or ERT (Roncagalli, R., et al. (2005). Nat. Immunol. 6(10):1002-1010). Clone 1A9 immunostained wild-type, but not sh2d1a-knockout murine peripheral blood CD3+CD4+ lymphocytes (Zhong, M.C., and Veillette, A. (2013). Mol. Cell. Biol. 33(6):1223-1232).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: CD99
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG3κ antibody in PBS without preservatives.
Gene Accession No.: P14209
Immunogen: Human thymocytes.
Quantity: 100 μg
Research Discipline: Inflammation, Immunology
Gene ID (Entrez): NP_001116370
Target Species: Human
Form: Purified
Applications: Functional Assay, Flow Cytometry, Western Blot
Clone: O662
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 0662 detects both the 32kDa glycosylated (plasma membrane) and the 28kDa non-glycosylated (intracellular) forms of human CD99/E2 (Gelin, C., et al. (1989). EMBO J. 8(11):3253-3259). Note that the clone was originally designated as 0662 (zero six six two) by Bernard, A., et al. (1988), but subsequently cited in some publications as O662 with a captial letter O.
Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype: IgG3 κ
Antigen:
CD99
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG3κ antibody in PBS without preservatives.
Gene Accession No.:
P14209
Immunogen:
Human thymocytes.
Quantity:
100 μg
Research Discipline:
Inflammation, Immunology
Gene ID (Entrez):
NP_001116370
Target Species:
Human
Form:
Purified
Applications:
Functional Assay, Flow Cytometry, Western Blot
Clone:
O662
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 0662 detects both the 32kDa glycosylated (plasma membrane) and the 28kDa non-glycosylated (intracellular) forms of human CD99/E2 (Gelin, C., et al. (1989). EMBO J. 8(11):3253-3259). Note that the clone was originally designated as 0662 (zero six six two) by Bernard, A., et al. (1988), but subsequently cited in some publications as O662 with a captial letter O.
Content And Storage:
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype:
IgG3 κ
Antigen: CD84/Slamf5
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q18PI6
Immunogen: Human IgG1 Fc-tagged recombinant mouse CD84 extracellular domain.
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_038517.1
Target Species: Mouse
Form: Purified
Applications: Flow Cytometry
Clone: 1D3
Conjugate: Unconjugated
Gene: Cd84, Slamf5
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1D3 immunostained the surface of murine CD84-transfected, but not untranfected, BI-141 murine T-cells (Cruz-Munoz, M.E., et al. (2009). Nat. Immunol. 10(3):297-305). Reactivity toward spliced isoform 2 has not been determined.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
CD84/Slamf5
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rat IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q18PI6
Immunogen:
Human IgG1 Fc-tagged recombinant mouse CD84 extracellular domain.
Quantity:
100 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_038517.1
Target Species:
Mouse
Form:
Purified
Applications:
Flow Cytometry
Clone:
1D3
Conjugate:
Unconjugated
Gene:
Cd84, Slamf5
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1D3 immunostained the surface of murine CD84-transfected, but not untranfected, BI-141 murine T-cells (Cruz-Munoz, M.E., et al. (2009). Nat. Immunol. 10(3):297-305). Reactivity toward spliced isoform 2 has not been determined.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: TCR Vγ1.1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: Irradiated TCR gamma/delta expressing T3 .13.1 hybridoma cells.
Quantity: 25 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): __
Target Species: Mouse
Form: Purified
Applications: Flow Cytometry, Immunoprecipitation
Clone: __
Conjugate: Unconjugated
Gene: __
Host Species: Armenian Hamster
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 2.11 detects T-cell receptor gamma chain C region C10.5 in lymphocytes.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG
Antigen:
TCR Vγ1.1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
Irradiated TCR gamma/delta expressing T3 .13.1 hybridoma cells.
Quantity:
25 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
__
Target Species:
Mouse
Form:
Purified
Applications:
Flow Cytometry, Immunoprecipitation
Clone:
__
Conjugate:
Unconjugated
Gene:
__
Host Species:
Armenian Hamster
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 2.11 detects T-cell receptor gamma chain C region C10.5 in lymphocytes.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG