MilliporeSigma™ VLDLR, Rat, Unlabeled, Clone: 4C4G5,

Description

• Pulmonary surfactant-associated protein D (UniProt P35247; also known as Collectin-7, Lung surfactant protein D, PSP-D, SP-D) is encoded by the SFTPD (also known as COLEC7, PSPD, SFTP4) gene (Gene ID 6441) in human
• Surfactant, produced by alveolar type II cells and airway Clara cells, resides at the air-liquid interface of the lungs and is most commonly known for its role in reducing surface tension
• Surfactant is a lipoprotein complex composed of approximately 10% proteins, including surfactant protein A (SP-A), SP-B, SP-C, and SP-D
• SP-A and SP-D belong to the collectin family of proteins and can modulate innate immunity
• SP-D is known to enhance pulmonary clearance of pathogens, such as Pseudomonous aerginosa, Klebsiella pneumonia, respiratory syncytial virus (RSV) and Influenza virus
• SP-D is also shown to modify allergic responsee in the lungs by binding common allergens, including house dust mite and pollen particles
• SP-A-deficient and SP-D-deficient mice are susceptible to bleomycin-induced lung injury and display increased cellular inflammation, more severe lung fibrosis, and reduced survival
• In addition to lung, SP-D is also reported to be detected in extrapulmonary tissues, such as kidney and pancreas
• Serum levels of either SP-A or SP-D in human are correlated with mortality in patients with pulmonary fibrosis
• Human SP-D is produced with a signal peptide sequence (a.a
• 1-20), which is removed posttranslationally to yield the mature protein (a.a
• 21-375) that contains a collagen-like domain (a.a
• 46-222), a coiled coil region (a.a
• 223-252), and a C-type lectin domain (a.a
• 260-375).