MABN1817
MilliporeSigma™ α-Synuclein, Mouse, Unlabeled, Clone: 2F12,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1817-Each-of-1 | In Stock | ₹ 44,046.29 |
MABN1817 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,046.29
GST (18%): ₹ 7,928.332
Total Price: ₹ 51,974.622
Antigen
α-Synuclein
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P37840
Immunogen
Purified human erythrocyte α-synuclein.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_000336
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
2F12
Conjugate
Unconjugated
Gene
SNCA, NACP, PARK1, PARK4
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 2F12 reacted with both monomeric and aggregated forms of alpha-synuclein of human, mouse, and rat species. Clone 2F12 detected both wild-type alpha-synuclein and fPD mutants (Dettmer, U., et al. (2015). Nat. Commun. 6:7314; Dettmer, U., et al. (2013). J. Biol. Chem. 288(9):6371-6385).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Alpha-synuclein (UniProt P37840; also known as NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Synuclein alpha-140) is encoded by the SNCA (also known as NACP, PARK1, PARK4) gene (Gene ID 6622) in human
- Pathological aggregates are common features of many neurodegenerative diseases, such as tau neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) and frontotemporal degeneration, and α-synuclein (α-syn or αS) Lewy bodies (LBs) in Parkinson's disease (PD) and dementia with LBs (DLB)
- Alpha-synuclein is a phospholipid-binding protein concentrated in presynaptic terminals where it promotes SNARE complex formation and modulates synaptic functions
- Alpha-synuclein is the major component of pathologic inclusions that characterize PD, DLB, and multiple system atrophy (MSA)
- Research shows that αS exists not only as unfolded monomers, but in large part also as multimers, principally as ∽60kDa tetramers composed of four N-acetylated αS, that assume α-helical conformation and resist aggregation
- PD-causing αS missense mutations are found to shift cellular αS from tetramers/multimers to monomers, indicating that decreased α-helical tetramers and increased unfolded monomers initiate pathogenesis
- In addition, both casein kinase-1 (CK-1) and CK-2 can catalyze the phosphorylation of αS on Ser129, and Ser129-phosphorylated αS is found in αS inclusions.
Compare Similar Items
Show Difference
Antigen: α-Synuclein
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P37840
Immunogen: Purified human erythrocyte α-synuclein.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_000336
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 2F12
Conjugate: Unconjugated
Gene: SNCA, NACP, PARK1, PARK4
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 2F12 reacted with both monomeric and aggregated forms of alpha-synuclein of human, mouse, and rat species. Clone 2F12 detected both wild-type alpha-synuclein and fPD mutants (Dettmer, U., et al. (2015). Nat. Commun. 6:7314; Dettmer, U., et al. (2013). J. Biol. Chem. 288(9):6371-6385).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
α-Synuclein
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P37840
Immunogen:
Purified human erythrocyte α-synuclein.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_000336
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
2F12
Conjugate:
Unconjugated
Gene:
SNCA, NACP, PARK1, PARK4
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 2F12 reacted with both monomeric and aggregated forms of alpha-synuclein of human, mouse, and rat species. Clone 2F12 detected both wild-type alpha-synuclein and fPD mutants (Dettmer, U., et al. (2015). Nat. Commun. 6:7314; Dettmer, U., et al. (2013). J. Biol. Chem. 288(9):6371-6385).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: α-Synuclein
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P37840
Immunogen: Purified human erythrocyte alpha-synuclein.
Quantity: 200 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_000336
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: SOY1
Conjugate: Unconjugated
Gene: SNCA, NACP, PARK1, PAR
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone SOY1 detected both wild-type alpha-synuclein and fPD mutants (Dettmer, U., et al. (2015). Nat. Commun. 6:7314). Clone SOY1 targets a C-terminal half epitope present in all three human spliced iisoforms, NACP140, NACP112, and NACP126, reported by UniProt (P37840). Clone SOY1 also exhibits murine cross-reactivity, albeit at a lower sensitivity than that of human alpha-synuclein.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
α-Synuclein
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P37840
Immunogen:
Purified human erythrocyte alpha-synuclein.
Quantity:
200 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_000336
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
SOY1
Conjugate:
Unconjugated
Gene:
SNCA, NACP, PARK1, PAR
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone SOY1 detected both wild-type alpha-synuclein and fPD mutants (Dettmer, U., et al. (2015). Nat. Commun. 6:7314). Clone SOY1 targets a C-terminal half epitope present in all three human spliced iisoforms, NACP140, NACP112, and NACP126, reported by UniProt (P37840). Clone SOY1 also exhibits murine cross-reactivity, albeit at a lower sensitivity than that of human alpha-synuclein.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: Atlastin-1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q8WXF7
Immunogen: Linear peptide corresponding to the N-terminal sequence of human Atlastin-1.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_056999
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 3194
Conjugate: Unconjugated
Gene: ATL1, GBP3, HSN1D, SPG3, SPG3A
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3194 targets an N-terminal epitope present in both spliced isoforms of human Atlastin-1 reported by UniProt (Q8WXF7).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Atlastin-1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q8WXF7
Immunogen:
Linear peptide corresponding to the N-terminal sequence of human Atlastin-1.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_056999
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
3194
Conjugate:
Unconjugated
Gene:
ATL1, GBP3, HSN1D, SPG3, SPG3A
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 3194 targets an N-terminal epitope present in both spliced isoforms of human Atlastin-1 reported by UniProt (Q8WXF7).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Filamin-A (Ser2152)
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P21333
Immunogen: KLH-conjugated linear peptide corresponding to the Filamin repeat 20 of human phospho-Filamin-A (Ser2152).
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001447
Target Species: Human, Mouse
Form: Purified
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Clone: PS2
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Ser2152 of human and murine Filamin-A isoform 1 (P21333-1 and Q8BTM8-1) corresponds to Ser2144 of human Filamin-A isoform 2 (P21333-2). Equivalent site is not present in murine spliced isoform 2.
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2b κ
Antigen:
Filamin-A (Ser2152)
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P21333
Immunogen:
KLH-conjugated linear peptide corresponding to the Filamin repeat 20 of human phospho-Filamin-A (Ser2152).
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001447
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Clone:
PS2
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Ser2152 of human and murine Filamin-A isoform 1 (P21333-1 and Q8BTM8-1) corresponds to Ser2144 of human Filamin-A isoform 2 (P21333-2). Equivalent site is not present in murine spliced isoform 2.
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2b κ