MABC1166MI
MilliporeSigma™ iASPP, Mouse, Unlabeled, Clone: LX128.5,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC1166MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABC1166MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
iASPP
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q8WUF5
Immunogen
Synthetic linear peptide corresponding to a sequence from the N-terminal region of human iASPP.
Quantity
100 μg
Research Discipline
Apoptosis & Cancer
Gene ID (Entrez)
NP_006654
Target Species
Mouse
Form
Purified
Applications
Immunohistochemistry (Paraffin)
Clone
LX128.5
Conjugate
Unconjugated
Gene
PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone LX128.5 immunostained intercalated discs in myocardial sections from wild-type, but not iASPP-deficient (iASPPδ8/δ8) adult mice (Notari, M., et al. (2015). Proc. Natl. Acad. Sci. U. S. A. 112(9):E973-E981).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- RelA-associated inhibitor (UniProt Q8WUF5; also known as Inhibitor of apoptosis-stimulating protein of p53, Inhibitor of ASPP protein, NF-kB-interacting protein 1, PPP1R13B-like protein, Protein iASPP) is encoded by the PPP1R13L (also known as IASPP, NKIP1, PPP1R13BL, RAI) gene (Gene ID 10848) in human
- Inhibitor of apoptosis-stimulating protein of p53 (iASPP) belongs to the ASPP family of proteins (ASPP1, ASPP2, and iASPP) characterized by their ankyrin repeats (a.a
- 659-691 and 692-724 in iASPP), SH3 domain (a.a
- 758-820 in iASPP), and proline-rich (a.a
- 54-602 in iASPP) sequences
- iASPP is expressed at intercalated discs in post-mitotic cardiomyocytes, where it interacts with desmoplakin and desmin in cardiomyocytes to help maintain the integrity of desmosomes and intermediate filament networks
- Desmosomes are anchoring junctions found in cells that endure physical stress such as cardiac myocytes or skin keratinocytes
- Mutations of genes coding desmosome components, including IASPP/PPP1R13L, are found in human patients suffering from cardiomyopathy and in animal models of cardiomyopathy
- iASPP deficiency caused by spontaneous mutation has been reported to be linked to a lethal autosomal recessive cardiomyopathy in Poll Hereford calves and Wa3 mice
- iASSP-deficient mice with exon 8 deletion display features of arrhythmogenic right ventricular cardiomyopathy (ARVC) and die of sudden cardiac death.
Compare Similar Items
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Antigen: iASPP
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q8WUF5
Immunogen: Synthetic linear peptide corresponding to a sequence from the N-terminal region of human iASPP.
Quantity: 100 μg
Research Discipline: Apoptosis & Cancer
Gene ID (Entrez): NP_006654
Target Species: Mouse
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: LX128.5
Conjugate: Unconjugated
Gene: PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone LX128.5 immunostained intercalated discs in myocardial sections from wild-type, but not iASPP-deficient (iASPPδ8/δ8) adult mice (Notari, M., et al. (2015). Proc. Natl. Acad. Sci. U. S. A. 112(9):E973-E981).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
iASPP
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q8WUF5
Immunogen:
Synthetic linear peptide corresponding to a sequence from the N-terminal region of human iASPP.
Quantity:
100 μg
Research Discipline:
Apoptosis & Cancer
Gene ID (Entrez):
NP_006654
Target Species:
Mouse
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
LX128.5
Conjugate:
Unconjugated
Gene:
PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone LX128.5 immunostained intercalated discs in myocardial sections from wild-type, but not iASPP-deficient (iASPPδ8/δ8) adult mice (Notari, M., et al. (2015). Proc. Natl. Acad. Sci. U. S. A. 112(9):E973-E981).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: MNDA
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat monoclonal antibody IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P41218
Immunogen: Human peripheral blood granulocyte nuclei.
Quantity: 100 μg
Research Discipline: Apoptosis & Cancer
Gene ID (Entrez): NP_002423
Target Species: Human
Form: Purified
Applications: Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 3C1
Conjugate: Unconjugated
Gene: MNDA
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3C1 reacted with both denatured and non-denatured MNDA. Clone 3C1 reacted with nuclear extract from NMDA-expressing HL-60, but not non-MNDA-expressing BII, human myeloid leukemia cells (Hudson, C.R., et al. (1988). Hybridoma. 7(6):541-553).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
MNDA
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rat monoclonal antibody IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P41218
Immunogen:
Human peripheral blood granulocyte nuclei.
Quantity:
100 μg
Research Discipline:
Apoptosis & Cancer
Gene ID (Entrez):
NP_002423
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
3C1
Conjugate:
Unconjugated
Gene:
MNDA
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 3C1 reacted with both denatured and non-denatured MNDA. Clone 3C1 reacted with nuclear extract from NMDA-expressing HL-60, but not non-MNDA-expressing BII, human myeloid leukemia cells (Hudson, C.R., et al. (1988). Hybridoma. 7(6):541-553).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: ALK
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal antibody IgG3 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: His-tagged full length human recombinant ALK tyrosine kinase receptor.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_004295
Target Species: Human
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: ALK1
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone ALK1 specifically detects human ALK tyrosine kinase receptor. It targets an epitope with in 102 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG3 κ
Antigen:
ALK
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal antibody IgG3 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
His-tagged full length human recombinant ALK tyrosine kinase receptor.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_004295
Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
ALK1
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone ALK1 specifically detects human ALK tyrosine kinase receptor. It targets an epitope with in 102 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG3 κ
Antigen: ALK
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal antibody IgG3 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: His-tagged full length human recombinant ALK tyrosine kinase receptor.
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_004295
Target Species: Human
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: ALK1
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone ALK1 specifically detects human ALK tyrosine kinase receptor. It targets an epitope with in 102 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG3 κ
Antigen:
ALK
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal antibody IgG3 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
His-tagged full length human recombinant ALK tyrosine kinase receptor.
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_004295
Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
ALK1
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone ALK1 specifically detects human ALK tyrosine kinase receptor. It targets an epitope with in 102 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG3 κ