MilliporeSigma™ SorLA, Mouse, Unlabeled, Clone: 20C11,

Description

• Sortilin-related receptor (UniProt Q92673; also known as Gp250, LDLR relative with 11 ligand-binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LR11, SorLA, SorLA-1, Sorting protein-related receptor containing LDLR class A repeats) is encoded by the SORL1 (also known as C11orf32) gene (Gene ID 6653) in human
• SorLA and Sortilin are related Vps10p-domain (Vsp10p-D) family multi-ligand-binding receptors that target LPL, growth factors and peptides, as well as soluble amyloid precursor proein (sAPP) for endocytosis
• Studies show that SorLA protects sAPP against proteolytic processing in compartments localized in the cell body (soma) of hippocampal neurons, whereas sortilin facilitates sAPP degradation by lysosomes localized in neurites
• Hippocampal neurons lacking sortilin display reduced sAPPα production, suggesting that sortilin promotes α-secretase activity in neuronal systems
• Unlike LRP1 and LRP1b, two other known sAPP-binding receptors, SorLA and Sortilin bind sAPP in a KPI domain-independent manner and their scavenging function therefore is not limited to sAPP produced from KPI-containing APP isoforms
• Human SorLA is a single transmembrane (a.a
• 2138-2158) protein with a 55-amino acid cytoplasmic tail (a.a
• 2159-2214) and a large luminal/extracellular (a.a
• 1-2137) region that contains a Vps10p-domain (Vsp10p-D; a.a
• 1-731) with a signal peptide (a.a
• 1-28) and a propeptide (a.a
• 29-81) sequence at the N-terminal end and five BNR (bacterial neuraminidase repeat or (F/Y)WTD/b-propeller domain) repeats (a.a
• 136-573)
• The C-terminal half of the luminal/extracellular region contains five LDL-R class B (LB) repeats (a.a
• 800-1013), an EGF-like domain (a.a
• 1026-1072), eleven LDL-R class A (LA) repeats (a.a
• 1076-1551), and six fibronectin type-III repeats (a.a
• 1557-2118).