MAC133MI
MilliporeSigma™ Cas9, Mouse, Unlabeled, Clone: 7A9,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MAC133MI-Each-of-1 | In Stock | ₹ 45,381.02 |
MAC133MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,381.02
GST (18%): ₹ 8,168.584
Total Price: ₹ 53,549.604
Antigen
Cas9
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Immunogen
N-Terminal domain of Cas9.
Quantity
100 μg
Research Discipline
Secondary & Control Antibodies
Test Specificity
MAC133 recognises both Cas9 and dCas9 (nuclease deficient Cas9)
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunoprecipitation, Western Blot
Clone
7A9
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
All species
Form
Purified
Related Products
Description
- Cas9 is an essential endonuclease in Streptococcus pyogenes serotype M1 that is part of that organism's innate immunity system, or CRISPR (clustered regularly interspaced short palindromic repeat) adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids)
- CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids
- CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)
- In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and Cas9
- Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
- The target strand not complementary to crRNA is first cut endonucleolytically, and then trimmed by 3&prime-5′ exonucleolytically
- DNA-binding requires protein and both RNA species
- Cas9 probably recognizes a short motif in the CRISPR repeat sequences (the PAM or to help distinguish self versus nonself
- Researchers hope to exploit the programmability and precise nature of Cas9 cleavage for more effective recombinant DNA technologies.
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Antigen: Cas9
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Immunogen: N-Terminal domain of Cas9.
Quantity: 100 μg
Research Discipline: Secondary & Control Antibodies
Test Specificity: MAC133 recognises both Cas9 and dCas9 (nuclease deficient Cas9)
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunoprecipitation, Western Blot
Clone: 7A9
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: All species
Form: Purified
Antigen:
Cas9
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Immunogen:
N-Terminal domain of Cas9.
Quantity:
100 μg
Research Discipline:
Secondary & Control Antibodies
Test Specificity:
MAC133 recognises both Cas9 and dCas9 (nuclease deficient Cas9)
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunoprecipitation, Western Blot
Clone:
7A9
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
All species
Form:
Purified
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Quantity:
4/Pk.
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Clone:
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Conjugate:
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