MABE1068MI
MilliporeSigma™ APE/Ref-1, Mouse, Unlabeled, Clone: 13B8E5C2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1068MI-Each-of-1 | In Stock | ₹ 37,453.03 |
MABE1068MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,453.03
GST (18%): ₹ 6,741.545
Total Price: ₹ 44,194.575
Antigen
APE/Ref-1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P27695
Immunogen
Recombinant full-length human APE/Ref-1.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_001632.2
Target Species
Human
Form
Purified
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
13B8E5C2
Conjugate
Unconjugated
Gene
APEX1, APE, APE1, APEX, APX, HAP1, REF1
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 13B8E5C2 detected both cytosolic and nuclear APE/Ref-1 by Immunocytochemistry, Immunohistochemistry, and Western blotting (Moore, D.H., et al. (2000). Clin. Cancer Res. 6(2):602-609).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18; UniProt P27695; also known as AP endonuclease 1, APE-1, APEN, APEX nuclease, Apurinic-apyrimidinic endonuclease 1, Redox factor-1, REF-1) is encoded by the APEX1 (also known as APE, APE1, APEX, APX, HAP1, REF1) gene (Gene ID 328) in human
- APE/Ref-1 mediates the cleavage of an apurinic/apyrimidinic (AP) site in DNA generated by DNA glycosylases during base excision repair (BER) in both nucleus and mitochondria
- APE/Ref-1 also functions as a redox factor (ref) responsible for maintaining several transcription factors (TFs) in an active reduced state for DNA binding, including AP-1, NF-κB, HIF-1α, CREB, TP53
- Elevated levels of APE1 are associated with resistance to chemotherapyand poor prognosis in various cancers
- APE/Ref-1 is synthesized as a 318-a.a
- protein whose initiation methionine (Met1) is removed posttranslationally to yield the 317-a.a
- form with a nuclear localization sequence (NLS; a.a
- 8-13) and a nuclear export signal (NES; a.a
- 64-80) sequence to allow its shuttle between the cytoplasm and nucleus
- The 317-a.a
- form can be further processed by a mitochondria-associated N-terminal peptidase into a mitochrondrial form (mtAPE; a.a
- 32-318) that lacks NLS and contains only the NES and the mitochondrial targeting sequence (MTS; a.a
- 289-318).
Compare Similar Items
Show Difference
Antigen: APE/Ref-1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P27695
Immunogen: Recombinant full-length human APE/Ref-1.
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_001632.2
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 13B8E5C2
Conjugate: Unconjugated
Gene: APEX1, APE, APE1, APEX, APX, HAP1, REF1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 13B8E5C2 detected both cytosolic and nuclear APE/Ref-1 by Immunocytochemistry, Immunohistochemistry, and Western blotting (Moore, D.H., et al. (2000). Clin. Cancer Res. 6(2):602-609).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
APE/Ref-1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P27695
Immunogen:
Recombinant full-length human APE/Ref-1.
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_001632.2
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
13B8E5C2
Conjugate:
Unconjugated
Gene:
APEX1, APE, APE1, APEX, APX, HAP1, REF1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 13B8E5C2 detected both cytosolic and nuclear APE/Ref-1 by Immunocytochemistry, Immunohistochemistry, and Western blotting (Moore, D.H., et al. (2000). Clin. Cancer Res. 6(2):602-609).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: BAP1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: GST-tagged full length recombinant human ubiquitin carboxyl-terminal hydrolase BAP1.
Quantity: 200 μL
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_004647
Target Species: Human
Form: Purified
Applications: Immunoprecipitation, Western Blot
Clone: 3C11
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3C11 specifically detects BAP1 in human. It targets an epitope within amino acids 337-440 in human BAP1.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
BAP1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
GST-tagged full length recombinant human ubiquitin carboxyl-terminal hydrolase BAP1.
Quantity:
200 μL
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_004647
Target Species:
Human
Form:
Purified
Applications:
Immunoprecipitation, Western Blot
Clone:
3C11
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 3C11 specifically detects BAP1 in human. It targets an epitope within amino acids 337-440 in human BAP1.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: BAP1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q92560
Immunogen: Recombinant full-length human BAP1.
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_004647
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 1G8
Conjugate: Unconjugated
Gene: BAP1, KIAA0272, hucep-6
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1G8 targets human BAP1 UCH domain.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
BAP1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q92560
Immunogen:
Recombinant full-length human BAP1.
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_004647
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
1G8
Conjugate:
Unconjugated
Gene:
BAP1, KIAA0272, hucep-6
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1G8 targets human BAP1 UCH domain.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: CtIP
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: GST-tagged recombinant fragment corresponding to 278 amino acids from the C-terminal half of human CtBP-interacting protein.
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_002885.1
Target Species: Human, Frog
Form: Purified
Applications: Western Blot, Affinity Purification, Immunohistochemistry (Paraffin)
Clone: 11-1
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 11-1 specifically detects CtBP-interacting protein in human tonsils and pancreas.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
CtIP
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant fragment corresponding to 278 amino acids from the C-terminal half of human CtBP-interacting protein.
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_002885.1
Target Species:
Human, Frog
Form:
Purified
Applications:
Western Blot, Affinity Purification, Immunohistochemistry (Paraffin)
Clone:
11-1
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 11-1 specifically detects CtBP-interacting protein in human tonsils and pancreas.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ