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MABC113125

PD-L1 B7-H1, Armenian Hamster anti-Mouse, Clone: 10B5, Millipore Sigma™

Manufacturer: Fischer Scientific

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Pack Size	SKU	Availability	Price
Each of 1	MABC113125-Each-of-1	In Stock	₹ 16,456.61

MABC113125 - Each of 1

₹ 16,456.61

In Stock

Quantity

Base Price: ₹ 16,456.61

GST (18%): ₹ 2,962.19

Total Price: ₹ 19,418.80

Antigen

PD-L1 B7-H1

Classification

Monoclonal

Conjugate

Unconjugated

Formulation

Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.

Gene Symbols

Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1

Immunogen

Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.

Quantity

25 μg

Research Discipline

Apoptosis & Cancer

Gene ID (Entrez)

NP_068693.1

Target Species

Mouse

Form

Purified

Applications

Flow Cytometry, Immunohistochemistry (Paraffin), Inhibition Assays

Clone

10B5

Dilution

Inhibits Activity/Function Analysis: A representative lot blocked the activity of PD-L1 B7-H1 and inhibited apoptosis of activated alloreactive 2C T cells. (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Goldberg, M.V., et. al. (2007). Blood. 110(1):186-92; Joshi, T., et. al. (2009). PLoS Pathog. 5(5):e1000431; Liu, X., et. al. (2016). Sci Rep. 6:36722). Flow Cytometry Analysis: A representative lot detected PD-L1 B7-H1 in Flow Cytometry applications (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Dong, H., et. al. (2004). Immunity. 20(3):327-36).

Gene Alias

Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274

Host Species

Armenian Hamster

Purification Method

Protein G purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

This Armenian hamster monoclonal antibody detects Programmed cell death 1 ligand 1 (PD-L1) in murine species.

Content And Storage

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

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Description

Anti-PD-L1 B7-H1, clone 10B5, Cat
No
MABC1131, is an Armenian hamster monoclonal antibody that detects Programmed cell death 1 ligand 1 (PD-L1) and has been tested for use in Flow Cytometry, Immunohistochemistry (Paraffin), and Inhibition Function assay
Programmed cell death 1 ligand 1 (UniProt: Q9EP73; also known as PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274) is encoded by the Cd274 (also known as B7h1, Pdcd1l1, Pdcd1lg1, Pdl1) gene (Gene ID: 50533) in murine species
PD-L1 is a single-pass type I membrane protein that is highly expressed in the heart, thymus, skeletal muscle, and lung
Its expression is also reported on activated dendritic cells, B-cells, and macrophages
Numerous tumor cell lines of lymphoid origin also express PD-L1
PD-L1 expression can be up-regulated by interferon-gamma treatment in monocytes, B cells, and macrophages
PD-1 and its ligands, PD-L1 and PD-L2 play a key role in the maintenance of peripheral tolerance, a process by which the quiescence of autoreactive mature T cells is maintained
However, tumors and pathogens that cause chronic infections can exploit this pathway to escape T-cell mediated tumor-specific and pathogen-specific immunity
The effector functions of T-cells expressing PD-1 can be downregulated by PD-L1 or PD-L2 expressed by the tumor cells
PD-L1 is initially produced with signal peptide (aa
1-18) sequence, the removal of which yields the mature protein with a large extracellular (aa
19-239) domain, a transmembrane domain (aa 240-260), and a cytoplasmic domain (aa 261-290).

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Fischer Scientific

MABC113125

Antigen:

PD-L1 B7-H1

Classification:

Monoclonal

Conjugate:

Unconjugated

Formulation:

Purified armenian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.

Gene Symbols:

Cd274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1

Immunogen:

Recombinant fragment corresponding to the extracellular domain of Mouse Programmed cell death 1 ligand 1.

Quantity:

25 μg

Research Discipline:

Apoptosis & Cancer

Gene ID (Entrez):

NP_068693.1

Target Species:

Mouse

Form:

Purified

Applications:

Flow Cytometry, Immunohistochemistry (Paraffin), Inhibition Assays

Clone:

10B5

Dilution:

Inhibits Activity/Function Analysis: A representative lot blocked the activity of PD-L1 B7-H1 and inhibited apoptosis of activated alloreactive 2C T cells. (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Goldberg, M.V., et. al. (2007). Blood. 110(1):186-92; Joshi, T., et. al. (2009). PLoS Pathog. 5(5):e1000431; Liu, X., et. al. (2016). Sci Rep. 6:36722). Flow Cytometry Analysis: A representative lot detected PD-L1 B7-H1 in Flow Cytometry applications (Hirano, F., et. al. (2005). Cancer Res. 65(3):1089-96; Dong, H., et. al. (2004). Immunity. 20(3):327-36).

Gene Alias:

Programmed cell death 1 ligand 1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274

Host Species:

Armenian Hamster

Purification Method:

Protein G purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Test Specificity:

This Armenian hamster monoclonal antibody detects Programmed cell death 1 ligand 1 (PD-L1) in murine species.

Content And Storage:

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

MilliporeSigma™

MABC1144MI

Antigen:

LMO-2 (Rhombotin-2)

Classification:

Monoclonal

Conjugate:

Unconjugated

Formulation:

Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Symbols:

__

Immunogen:

GST-tagged recombinant human LMO-2 (Rhombotin-2).

Quantity:

100 μg

Research Discipline:

Apoptosis & Cancer

Gene ID (Entrez):

NP_005565.2

Target Species:

Human

Form:

Purified

Applications:

Immunohistochemistry (Paraffin)

Clone:

1A9-3B11

Dilution:

Gene Alias:

Host Species:

Mouse

Purification Method:

Protein G Purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Test Specificity:

__

Content And Storage:

Stable for 1 year at 2°-8°C from date of receipt.

Sigma Aldrich

MABC1145

clone 73.3, from mouse...

Antigen:

Classification:

Conjugate:

Formulation:

Gene Symbols:

Immunogen:

Quantity:

Research Discipline:

Gene ID (Entrez):

Target Species:

Form:

Applications:

Clone:

Dilution:

Gene Alias:

Host Species:

Purification Method:

Regulatory Status:

Primary or Secondary:

Test Specificity:

Content And Storage:

__

MilliporeSigma

MABC1147MI

Antigen:

CIP2A

Classification:

Monoclonal

Conjugate:

Unconjugated

Formulation:

__

Gene Symbols:

KIAA1524:CIP2A

Immunogen:

His-tagged recombinant fragment from the N-terminal region of human CIP2A.

Quantity:

100 μg

Research Discipline:

Apoptosis and Cancer

Gene ID (Entrez):

NP_065941

Target Species:

Human

Form:

Purified

Applications:

Western Blot

Clone:

6G8-G1

Dilution:

Gene Alias:

Host Species:

Mouse

Purification Method:

Protein G Purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Test Specificity:

Clone 6G8-G1 specifically detects CIP2A in HEK293 cells overexpressing CIP2A.

Content And Storage:

Stable for 1 year at 2-8°C from date of receipt.

PD-L1 B7-H1, Armenian Hamster anti-Mouse, Clone: 10B5, Millipore Sigma™

Select a Size

Select a Size

Properties

Antigen

Classification

Conjugate

Formulation

Gene Symbols

Immunogen

Quantity

Research Discipline

Gene ID (Entrez)

Target Species

Form

Applications

Clone

Dilution

Gene Alias

Host Species

Purification Method

Regulatory Status

Primary or Secondary

Test Specificity

Content And Storage

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Description

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Fischer Scientific

MilliporeSigma™

Sigma Aldrich

MilliporeSigma